1t9h

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{{Seed}}
 
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[[Image:1t9h.png|left|200px]]
 
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==The crystal structure of YloQ, a circularly permuted GTPase.==
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The line below this paragraph, containing "STRUCTURE_1t9h", creates the "Structure Box" on the page.
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<StructureSection load='1t9h' size='340' side='right'caption='[[1t9h]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1t9h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T9H FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IUM:URANYL+(VI)+ION'>IUM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1t9h| PDB=1t9h | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t9h OCA], [https://pdbe.org/1t9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t9h RCSB], [https://www.ebi.ac.uk/pdbsum/1t9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t9h ProSAT]</span></td></tr>
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</table>
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===The crystal structure of YloQ, a circularly permuted GTPase.===
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== Function ==
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[https://www.uniprot.org/uniprot/RSGA_BACSU RSGA_BACSU] Depletion of yloQ results in sensitization towards protein synthesis inhibitors that block the peptide channel or peptidyl transferase center on the ribosome, implying that YloQ functions in conjunction with the ribosome in vivo. Decreasing levels of YloQ lead to an increase in unassembled 30S and 50S subunit and a decrease in the assembled 70S ribosome. May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity). Dispensible for viability, but important for overall fitness.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_15223319}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 15223319 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t9/1t9h_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_15223319}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1T9H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T9H OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t9h ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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The crystal structure of YloQ, a circularly permuted GTPase essential for Bacillus subtilis viability., Levdikov VM, Blagova EV, Brannigan JA, Cladiere L, Antson AA, Isupov MN, Seror SJ, Wilkinson AJ, J Mol Biol. 2004 Jul 16;340(4):767-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15223319 15223319]
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</StructureSection>
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Crystallization of YloQ, a GTPase of unknown function essential for Bacillus subtilis viability., Cladiere L, Blagova E, Levdikov VM, Brannigan JA, Seror SJ, Wilkinson AJ, Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):329-30. Epub 2004, Jan 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14747714 14747714]
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[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Antson, A A.]]
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[[Category: Antson AA]]
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[[Category: Blagova, E V.]]
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[[Category: Blagova EV]]
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[[Category: Brannigan, J A.]]
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[[Category: Brannigan JA]]
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[[Category: Cladiere, L.]]
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[[Category: Cladiere L]]
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[[Category: Isupov, M N.]]
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[[Category: Isupov MN]]
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[[Category: Levdikov, V M.]]
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[[Category: Levdikov VM]]
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[[Category: Seror, S J.]]
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[[Category: Seror SJ]]
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[[Category: Wilkinson, A J.]]
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[[Category: Wilkinson AJ]]
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[[Category: C-terminal zinc-binding domain]]
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[[Category: Central gtp binding domain]]
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[[Category: N-terminal beta-barrel domain with oligonucleotide binding fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:51:52 2008''
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Current revision

The crystal structure of YloQ, a circularly permuted GTPase.

PDB ID 1t9h

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