2o3x

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:30, 30 August 2023) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2o3x.png|left|200px]]
 
-
<!--
+
==Crystal Structure of the Prokaryotic Ribosomal Decoding Site Complexed with Paromamine Derivative NB30==
-
The line below this paragraph, containing "STRUCTURE_2o3x", creates the "Structure Box" on the page.
+
<StructureSection load='2o3x' size='340' side='right'caption='[[2o3x]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2o3x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O3X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O3X FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N30:(1R,2R,3S,4R,6S)-4,6-DIAMINO-2-[(5-AMINO-5-DEOXY-BETA-D-RIBOFURANOSYL)OXY]-3-HYDROXYCYCLOHEXYL+2-AMINO-2-DEOXY-ALPHA-D-GLUCOPYRANOSIDE'>N30</scene></td></tr>
-
{{STRUCTURE_2o3x| PDB=2o3x | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o3x OCA], [https://pdbe.org/2o3x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o3x RCSB], [https://www.ebi.ac.uk/pdbsum/2o3x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o3x ProSAT]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The lack of absolute prokaryotic selectivity of natural antibiotics is widespread and is a significant clinical problem. The use of this disadvantage of aminoglycoside antibiotics for the possible treatment of human genetic diseases is extremely challenging. Here, we have used a combination of biochemical and structural analysis to compare and contrast the molecular mechanisms of action and the structure-activity relationships of a new synthetic aminoglycoside, NB33, and a structurally similar natural aminoglycoside apramycin. The data presented herein demonstrate the general molecular principles that determine the decreased selectivity of apramycin for the prokaryotic decoding site, and the increased selectivity of NB33 for the eukaryotic decoding site. These results are therefore extremely beneficial for further research on both the design of new aminoglycoside-based antibiotics with diminished deleterious effects on humans, as well as the design of new aminoglycoside-based structures that selectively target the eukaryotic ribosome.
-
===Crystal Structure of the Prokaryotic Ribosomal Decoding Site Complexed with Paromamine Derivative NB30===
+
Differential selectivity of natural and synthetic aminoglycosides towards the eukaryotic and prokaryotic decoding A sites.,Kondo J, Hainrichson M, Nudelman I, Shallom-Shezifi D, Barbieri CM, Pilch DS, Westhof E, Baasov T Chembiochem. 2007 Sep 24;8(14):1700-9. PMID:17705310<ref>PMID:17705310</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_17705310}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 2o3x" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 17705310 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_17705310}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
2O3X is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O3X OCA].
+
[[Category: Baasov T]]
-
 
+
[[Category: Hainrichson M]]
-
==Reference==
+
[[Category: Kondo J]]
-
Differential selectivity of natural and synthetic aminoglycosides towards the eukaryotic and prokaryotic decoding A sites., Kondo J, Hainrichson M, Nudelman I, Shallom-Shezifi D, Barbieri CM, Pilch DS, Westhof E, Baasov T, Chembiochem. 2007 Sep 24;8(14):1700-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17705310 17705310]
+
[[Category: Nudelman I]]
-
[[Category: Single protein]]
+
[[Category: Shallom-Shezifi D]]
-
[[Category: Baasov, T.]]
+
[[Category: Westhof E]]
-
[[Category: Hainrichson, M.]]
+
-
[[Category: Kondo, J.]]
+
-
[[Category: Nudelman, I.]]
+
-
[[Category: Shallom-Shezifi, D.]]
+
-
[[Category: Westhof, E.]]
+
-
[[Category: Aminoglycoside]]
+
-
[[Category: Antibiotic]]
+
-
[[Category: Decoding site]]
+
-
[[Category: Prokaryote]]
+
-
[[Category: Ribosome]]
+
-
[[Category: Rna]]
+
-
[[Category: Stop codon readthrough]]
+
-
[[Category: Translation inhibition]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:52:07 2008''
+

Current revision

Crystal Structure of the Prokaryotic Ribosomal Decoding Site Complexed with Paromamine Derivative NB30

PDB ID 2o3x

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2o3x"
Personal tools