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2q5e

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{{Seed}}
 
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[[Image:2q5e.png|left|200px]]
 
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<!--
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==Crystal structure of human carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2==
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The line below this paragraph, containing "STRUCTURE_2q5e", creates the "Structure Box" on the page.
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<StructureSection load='2q5e' size='340' side='right'caption='[[2q5e]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2q5e]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q5E FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_2q5e| PDB=2q5e | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q5e OCA], [https://pdbe.org/2q5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q5e RCSB], [https://www.ebi.ac.uk/pdbsum/2q5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q5e ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2q5e TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CTDS2_HUMAN CTDS2_HUMAN] Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.<ref>PMID:12721286</ref> <ref>PMID:15681389</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q5/2q5e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q5e ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2===
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==See Also==
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_18058037}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18058037 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_18058037}}
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==About this Structure==
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2Q5E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q5E OCA].
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==Reference==
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Structural genomics of protein phosphatases., Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK, J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18058037 18058037]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphoprotein phosphatase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Almo SC]]
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[[Category: Almo, S C.]]
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[[Category: Bain KT]]
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[[Category: Bain, K T.]]
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[[Category: Bonanno JB]]
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[[Category: Bonanno, J B.]]
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[[Category: Burley SK]]
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[[Category: Burley, S K.]]
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[[Category: Dickey M]]
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[[Category: Dickey, M.]]
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[[Category: Lau C]]
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[[Category: Lau, C.]]
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[[Category: Romero R]]
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[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
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[[Category: Sauder JM]]
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[[Category: Romero, R.]]
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[[Category: Smith D]]
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[[Category: Sauder, J M.]]
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[[Category: Wasserman S]]
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[[Category: Smith, D.]]
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[[Category: Wasserman, S.]]
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[[Category: Hydrolase]]
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[[Category: New york structural genomix research consortium]]
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[[Category: Nysgxrc]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:54:37 2008''
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Current revision

Crystal structure of human carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

PDB ID 2q5e

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