1zdx

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{{Seed}}
 
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[[Image:1zdx.png|left|200px]]
 
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==Solution Structure of the type 1 pilus assembly platform FimD(25-125)==
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The line below this paragraph, containing "STRUCTURE_1zdx", creates the "Structure Box" on the page.
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<StructureSection load='1zdx' size='340' side='right'caption='[[1zdx]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1zdx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZDX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zdx OCA], [https://pdbe.org/1zdx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zdx RCSB], [https://www.ebi.ac.uk/pdbsum/1zdx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zdx ProSAT]</span></td></tr>
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{{STRUCTURE_1zdx| PDB=1zdx | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FIMD_ECOLI FIMD_ECOLI] Involved in the export and assembly of FimA fimbrial subunits across the outer membrane.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zd/1zdx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zdx ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Adhesive type 1 pili from uropathogenic Escherichia coli are filamentous protein complexes that are attached to the assembly platform FimD in the outer membrane. During pilus assembly, FimD binds complexes between the chaperone FimC and type 1 pilus subunits in the periplasm and mediates subunit translocation to the cell surface. Here we report nuclear magnetic resonance and X-ray protein structures of the N-terminal substrate recognition domain of FimD (FimD(N)) before and after binding of a chaperone-subunit complex. FimD(N) consists of a flexible N-terminal segment of 24 residues, a structured core with a novel fold, and a C-terminal hinge segment. In the ternary complex, residues 1-24 of FimD(N) specifically interact with both FimC and the subunit, acting as a sensor for loaded FimC molecules. Together with in vivo complementation studies, we show how this mechanism enables recognition and discrimination of different chaperone-subunit complexes by bacterial pilus assembly platforms.
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===Solution Structure of the type 1 pilus assembly platform FimD(25-125)===
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Structural basis of chaperone-subunit complex recognition by the type 1 pilus assembly platform FimD.,Nishiyama M, Horst R, Eidam O, Herrmann T, Ignatov O, Vetsch M, Bettendorff P, Jelesarov I, Grutter MG, Wuthrich K, Glockshuber R, Capitani G EMBO J. 2005 Jun 15;24(12):2075-86. Epub 2005 May 26. PMID:15920478<ref>PMID:15920478</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<!--
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15920478}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1zdx" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15920478 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15920478}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1ZDX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZDX OCA].
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==Reference==
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Structural basis of chaperone-subunit complex recognition by the type 1 pilus assembly platform FimD., Nishiyama M, Horst R, Eidam O, Herrmann T, Ignatov O, Vetsch M, Bettendorff P, Jelesarov I, Grutter MG, Wuthrich K, Glockshuber R, Capitani G, EMBO J. 2005 Jun 15;24(12):2075-86. Epub 2005 May 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15920478 15920478]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bettendorff, P.]]
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[[Category: Bettendorff P]]
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[[Category: Capitani, G.]]
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[[Category: Capitani G]]
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[[Category: Glockshuber, R.]]
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[[Category: Glockshuber R]]
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[[Category: Grutter, M.]]
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[[Category: Grutter M]]
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[[Category: Herrmann, T.]]
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[[Category: Herrmann T]]
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[[Category: Horst, R.]]
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[[Category: Horst R]]
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[[Category: Ignatov, O.]]
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[[Category: Ignatov O]]
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[[Category: Nishiyama, M.]]
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[[Category: Nishiyama M]]
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[[Category: Vetsch, M.]]
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[[Category: Vetsch M]]
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[[Category: Wuthrich, K.]]
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[[Category: Wuthrich K]]
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[[Category: Alpha helix]]
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[[Category: Beta sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:04:43 2008''
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Current revision

Solution Structure of the type 1 pilus assembly platform FimD(25-125)

PDB ID 1zdx

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