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1pu6

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{{Seed}}
 
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[[Image:1pu6.png|left|200px]]
 
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==Crystal structure of H.pylori 3-methyladenine DNA glycosylase (MagIII)==
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The line below this paragraph, containing "STRUCTURE_1pu6", creates the "Structure Box" on the page.
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<StructureSection load='1pu6' size='340' side='right'caption='[[1pu6]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pu6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PU6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PU6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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{{STRUCTURE_1pu6| PDB=1pu6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pu6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pu6 OCA], [https://pdbe.org/1pu6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pu6 RCSB], [https://www.ebi.ac.uk/pdbsum/1pu6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pu6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O25323_HELPY O25323_HELPY] DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity (By similarity).[PIRNR:PIRNR001435]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pu/1pu6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pu6 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of H.pylori 3-methyladenine DNA glycosylase (MagIII)===
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==See Also==
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*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_14517230}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14517230 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14517230}}
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==About this Structure==
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1PU6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PU6 OCA].
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==Reference==
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Crystal structures of 3-methyladenine DNA glycosylase MagIII and the recognition of alkylated bases., Eichman BF, O'Rourke EJ, Radicella JP, Ellenberger T, EMBO J. 2003 Oct 1;22(19):4898-909. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14517230 14517230]
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[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Eichman, B F.]]
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[[Category: Eichman BF]]
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[[Category: Ellenberger, T.]]
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[[Category: Ellenberger T]]
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[[Category: Radicella, J P.]]
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[[Category: O'Rourke EJ]]
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[[Category: Rourke, E J.O.]]
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[[Category: Radicella JP]]
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[[Category: 3-methyladenine]]
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[[Category: Base excision repair]]
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[[Category: Glycosylase]]
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[[Category: Helix-hairpin-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:13:42 2008''
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Current revision

Crystal structure of H.pylori 3-methyladenine DNA glycosylase (MagIII)

PDB ID 1pu6

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