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1p8j

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{{Seed}}
 
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[[Image:1p8j.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN==
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The line below this paragraph, containing "STRUCTURE_1p8j", creates the "Structure Box" on the page.
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<StructureSection load='1p8j' size='340' side='right'caption='[[1p8j]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1p8j]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P8J FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=AR7:AMINO{[(4S)-4-AMINO-5,5-DIHYDROXYPENTYL]AMINO}METHANIMINIUM'>AR7</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DKA:DECANOIC+ACID'>DKA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1p8j| PDB=1p8j | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p8j OCA], [https://pdbe.org/1p8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p8j RCSB], [https://www.ebi.ac.uk/pdbsum/1p8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p8j ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FURIN_MOUSE FURIN_MOUSE] Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p8/1p8j_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p8j ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN===
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==See Also==
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*[[Furin|Furin]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12794637}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12794637 is the PubMed ID number.
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-->
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{{ABSTRACT_PUBMED_12794637}}
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==About this Structure==
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1P8J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8J OCA].
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==Reference==
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The crystal structure of the proprotein processing proteinase furin explains its stringent specificity., Henrich S, Cameron A, Bourenkov GP, Kiefersauer R, Huber R, Lindberg I, Bode W, Than ME, Nat Struct Biol. 2003 Jul;10(7):520-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12794637 12794637]
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[[Category: Furin]]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Bode W]]
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[[Category: Bode, W.]]
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[[Category: Bourenkov GP]]
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[[Category: Bourenkov, G P.]]
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[[Category: Cameron A]]
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[[Category: Cameron, A.]]
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[[Category: Henrich S]]
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[[Category: Henrich, S.]]
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[[Category: Huber R]]
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[[Category: Huber, R.]]
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[[Category: Kiefersauer R]]
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[[Category: Kiefersauer, R.]]
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[[Category: Lindberg I]]
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[[Category: Lindberg, I.]]
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[[Category: Than ME]]
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[[Category: Than, M E.]]
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[[Category: Chloromethylketone]]
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[[Category: P-domain]]
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[[Category: Pace]]
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[[Category: Prohormone convertase]]
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[[Category: Spc1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:18:10 2008''
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Current revision

CRYSTAL STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN

PDB ID 1p8j

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