1qf8

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{{Seed}}
 
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[[Image:1qf8.png|left|200px]]
 
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==TRUNCATED FORM OF CASEIN KINASE II BETA SUBUNIT (2-182) FROM HOMO SAPIENS==
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The line below this paragraph, containing "STRUCTURE_1qf8", creates the "Structure Box" on the page.
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<StructureSection load='1qf8' size='340' side='right'caption='[[1qf8]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qf8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QF8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1qf8| PDB=1qf8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qf8 OCA], [https://pdbe.org/1qf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qf8 RCSB], [https://www.ebi.ac.uk/pdbsum/1qf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qf8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CSK2B_HUMAN CSK2B_HUMAN] Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.<ref>PMID:11239457</ref> <ref>PMID:16818610</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qf/1qf8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qf8 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Protein kinase CK2 is a tetramer composed of two alpha catalytic subunits and two beta regulatory subunits. The structure of a C-terminal truncated form of the human beta subunit has been determined by X-ray crystallography to 1.7 A resolution. One dimer is observed in the asymmetric unit of the crystal. The most striking feature of the structure is the presence of a zinc finger mediating the dimerization. The monomer structure consists of two domains, one entirely alpha-helical and one including the zinc finger. The dimer has a crescent shape holding a highly acidic region at both ends. We propose that this acidic region is involved in the interactions with the polyamines and/or catalytic subunits. Interestingly, conserved amino acid residues among beta subunit sequences are clustered along one linear ridge that wraps around the entire dimer. This feature suggests that protein partners may interact with the dimer through a stretch of residues in an extended conformation.
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===TRUNCATED FORM OF CASEIN KINASE II BETA SUBUNIT (2-182) FROM HOMO SAPIENS===
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Crystal structure of the human protein kinase CK2 regulatory subunit reveals its zinc finger-mediated dimerization.,Chantalat L, Leroy D, Filhol O, Nueda A, Benitez MJ, Chambaz EM, Cochet C, Dideberg O EMBO J. 1999 Jun 1;18(11):2930-40. PMID:10357806<ref>PMID:10357806</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1qf8" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_10357806}}, adds the Publication Abstract to the page
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*[[Casein kinase 3D structures|Casein kinase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10357806 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10357806}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1QF8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QF8 OCA].
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==Reference==
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Crystal structure of the human protein kinase CK2 regulatory subunit reveals its zinc finger-mediated dimerization., Chantalat L, Leroy D, Filhol O, Nueda A, Benitez MJ, Chambaz EM, Cochet C, Dideberg O, EMBO J. 1999 Jun 1;18(11):2930-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10357806 10357806]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Benitez MJ]]
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[[Category: Benitez, M J.]]
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[[Category: Chambaz E]]
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[[Category: Chambaz, E.]]
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[[Category: Chantalat L]]
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[[Category: Chantalat, L.]]
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[[Category: Cochet C]]
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[[Category: Cochet, C.]]
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[[Category: Dideberg O]]
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[[Category: Dideberg, O.]]
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[[Category: Filhol O]]
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[[Category: Filhol, O.]]
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[[Category: Leroy D]]
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[[Category: Leroy, D.]]
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[[Category: Nueda A]]
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[[Category: Nueda, A.]]
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[[Category: Ser/thr protein kinase]]
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[[Category: Zn finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:18:18 2008''
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Current revision

TRUNCATED FORM OF CASEIN KINASE II BETA SUBUNIT (2-182) FROM HOMO SAPIENS

PDB ID 1qf8

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