1s9h
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:1s9h.png|left|200px]] | ||
| - | + | ==Crystal Structure of Adeno-associated virus Type 2 Rep40== | |
| - | + | <StructureSection load='1s9h' size='340' side='right'caption='[[1s9h]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1s9h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Adeno-associated_virus_2 Adeno-associated virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S9H FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s9h OCA], [https://pdbe.org/1s9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s9h RCSB], [https://www.ebi.ac.uk/pdbsum/1s9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s9h ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/REP68_AAV2S REP68_AAV2S] Plays an essential role in the initiation of viral DNA synthesis. Binds specifically to an inverted terminal repeat element (ITR) on the 3' and 5' ends of the viral DNA, where it cleaves a site specifically to generate a priming site for initiation of the synthesis of a complementary strand. Plays also a role as transcriptional regulator, DNA helicase and as key factor in site-specific integration of the viral genome. Inhibits the host cell cycle G1/S and G2/M transitions. These arrests may provide essential cellular factors for viral DNA replication.<ref>PMID:9882364</ref> | |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | < | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s9/1s9h_consurf.spt"</scriptWhenChecked> | |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | + | </jmolCheckbox> | |
| - | == | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s9h ConSurf]. |
| - | + | <div style="clear:both"></div> | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Adeno-associated virus 2]] | [[Category: Adeno-associated virus 2]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Aggarwal | + | [[Category: Aggarwal AK]] |
| - | [[Category: Edwards | + | [[Category: Edwards TA]] |
| - | [[Category: Escalante | + | [[Category: Escalante CR]] |
| - | [[Category: James | + | [[Category: James JA]] |
| - | [[Category: Linden | + | [[Category: Linden RM]] |
| - | [[Category: Yoon-Robarts | + | [[Category: Yoon-Robarts M]] |
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Current revision
Crystal Structure of Adeno-associated virus Type 2 Rep40
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