1o0v

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{{Seed}}
 
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[[Image:1o0v.png|left|200px]]
 
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==The crystal structure of IgE Fc reveals an asymmetrically bent conformation==
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The line below this paragraph, containing "STRUCTURE_1o0v", creates the "Structure Box" on the page.
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<StructureSection load='1o0v' size='340' side='right'caption='[[1o0v]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1o0v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ls0 1ls0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O0V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O0V FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1o0v| PDB=1o0v | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o0v OCA], [https://pdbe.org/1o0v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o0v RCSB], [https://www.ebi.ac.uk/pdbsum/1o0v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o0v ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IGHE_HUMAN IGHE_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o0/1o0v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o0v ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The distinguishing structural feature of immunoglobulin E (IgE), the antibody responsible for allergic hypersensitivity, is the C epsilon 2 domain pair that replaces the hinge region of IgG. The crystal structure of the IgE Fc (constant fragment) at a 2.6-A resolution has revealed these domains. They display a distinctive, disulfide-linked Ig domain interface and are folded back asymmetrically onto the C epsilon 3 and C epsilon 4 domains, which causes an acute bend in the IgE molecule. The structure implies that a substantial conformational change involving C epsilon 2 must accompany binding to the mast cell receptor Fc epsilon RI. This may be the basis of the exceptionally slow dissociation rate of the IgE-Fc epsilon RI complex and, thus, of the ability of IgE to cause persistent allergic sensitization of mast cells.
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===The crystal structure of IgE Fc reveals an asymmetrically bent conformation===
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The crystal structure of IgE Fc reveals an asymmetrically bent conformation.,Wan T, Beavil RL, Fabiane SM, Beavil AJ, Sohi MK, Keown M, Young RJ, Henry AJ, Owens RJ, Gould HJ, Sutton BJ Nat Immunol. 2002 Jul;3(7):681-6. Epub 2002 Jun 17. PMID:12068291<ref>PMID:12068291</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12068291}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1o0v" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12068291 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12068291}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1O0V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O0V OCA].
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==Reference==
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The crystal structure of IgE Fc reveals an asymmetrically bent conformation., Wan T, Beavil RL, Fabiane SM, Beavil AJ, Sohi MK, Keown M, Young RJ, Henry AJ, Owens RJ, Gould HJ, Sutton BJ, Nat Immunol. 2002 Jul;3(7):681-6. Epub 2002 Jun 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12068291 12068291]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Beavil, A J.]]
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[[Category: Beavil AJ]]
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[[Category: Beavil, R L.]]
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[[Category: Beavil RL]]
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[[Category: Fabiane, S M.]]
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[[Category: Fabiane SM]]
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[[Category: Gould, H J.]]
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[[Category: Gould HJ]]
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[[Category: Henry, A J.]]
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[[Category: Henry AJ]]
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[[Category: Keown, M.]]
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[[Category: Keown M]]
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[[Category: Owens, R J.]]
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[[Category: Owens RJ]]
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[[Category: Sohi, M K.]]
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[[Category: Sohi MK]]
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[[Category: Sutton, B J.]]
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[[Category: Sutton BJ]]
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[[Category: Wan, T.]]
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[[Category: Wan T]]
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[[Category: Young, R J.]]
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[[Category: Young RJ]]
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[[Category: Ige fc]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin e]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:31:27 2008''
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Current revision

The crystal structure of IgE Fc reveals an asymmetrically bent conformation

PDB ID 1o0v

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