1kzq

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(New page: 200px<br /><applet load="1kzq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kzq, resolution 1.7&Aring;" /> '''crystal structure of ...)
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[[Image:1kzq.jpg|left|200px]]<br /><applet load="1kzq" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1kzq, resolution 1.7&Aring;" />
 
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'''crystal structure of a parasite protein'''<br />
 
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==Overview==
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==crystal structure of a parasite protein==
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Toxoplasma gondii is a persistent protozoan parasite capable of infecting, almost any warm-blooded vertebrate. The surface of Toxoplasma is coated, with a family of developmentally regulated glycosylphosphatidylinositol, (GPI)-linked proteins (SRSs), of which SAG1 is the prototypic member. SRS, proteins mediate attachment to host cells and interface with the host, immune response to regulate the virulence of the parasite. The 1.7 A, structure of the immunodominant SAG1 antigen reveals a homodimeric, configuration in which the dimeric interface is mediated by an extended, beta-sheet that forms a deep groove lined with positively charged amino, acids. This basic groove seems to be conserved among SRS proteins and, potentially serves as a sulfated proteoglycan-binding site on target cell, surfaces, thus rationalizing the promiscuous attachment properties of, Toxoplasma to a broad range of host cell types.
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<StructureSection load='1kzq' size='340' side='right'caption='[[1kzq]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1kzq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KZQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kzq OCA], [https://pdbe.org/1kzq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kzq RCSB], [https://www.ebi.ac.uk/pdbsum/1kzq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kzq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P30_TOXGO P30_TOXGO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/1kzq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kzq ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Toxoplasma gondii is a persistent protozoan parasite capable of infecting almost any warm-blooded vertebrate. The surface of Toxoplasma is coated with a family of developmentally regulated glycosylphosphatidylinositol (GPI)-linked proteins (SRSs), of which SAG1 is the prototypic member. SRS proteins mediate attachment to host cells and interface with the host immune response to regulate the virulence of the parasite. The 1.7 A structure of the immunodominant SAG1 antigen reveals a homodimeric configuration in which the dimeric interface is mediated by an extended beta-sheet that forms a deep groove lined with positively charged amino acids. This basic groove seems to be conserved among SRS proteins and potentially serves as a sulfated proteoglycan-binding site on target cell surfaces, thus rationalizing the promiscuous attachment properties of Toxoplasma to a broad range of host cell types.
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==About this Structure==
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Structure of the immunodominant surface antigen from the Toxoplasma gondii SRS superfamily.,He XL, Grigg ME, Boothroyd JC, Garcia KC Nat Struct Biol. 2002 Aug;9(8):606-11. PMID:12091874<ref>PMID:12091874</ref>
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1KZQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1KZQ OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structure of the immunodominant surface antigen from the Toxoplasma gondii SRS superfamily., He XL, Grigg ME, Boothroyd JC, Garcia KC, Nat Struct Biol. 2002 Aug;9(8):606-11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12091874 12091874]
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</div>
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[[Category: Single protein]]
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<div class="pdbe-citations 1kzq" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Toxoplasma gondii]]
[[Category: Toxoplasma gondii]]
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[[Category: Boothroyd, J.C.]]
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[[Category: Boothroyd JC]]
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[[Category: Garcia, K.C.]]
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[[Category: Garcia KC]]
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[[Category: Grigg, M.E.]]
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[[Category: Grigg ME]]
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[[Category: He, X.]]
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[[Category: He X]]
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[[Category: crystal structure]]
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[[Category: mad]]
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[[Category: major surface antigen]]
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[[Category: parasite invasion]]
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[[Category: sag1]]
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[[Category: toxoplasma gondii]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 20:06:27 2007''
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Current revision

crystal structure of a parasite protein

PDB ID 1kzq

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