1nra

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:52, 10 April 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1nra.png|left|200px]]
 
-
<!--
+
==SOLUTION STRUCTURE OF AN OLD WORLD-LIKE NEUROTOXIN FROM THE VENOM OF THE NEW WORLD SCORPION CENTRUROIDES SCULPTURATUS EWING==
-
The line below this paragraph, containing "STRUCTURE_1nra", creates the "Structure Box" on the page.
+
<StructureSection load='1nra' size='340' side='right'caption='[[1nra]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1nra]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Centruroides_sculpturatus Centruroides sculpturatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NRA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NRA FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nra OCA], [https://pdbe.org/1nra PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nra RCSB], [https://www.ebi.ac.uk/pdbsum/1nra PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nra ProSAT]</span></td></tr>
-
{{STRUCTURE_1nra| PDB=1nra | SCENE= }}
+
</table>
-
 
+
== Function ==
-
===SOLUTION STRUCTURE OF AN OLD WORLD-LIKE NEUROTOXIN FROM THE VENOM OF THE NEW WORLD SCORPION CENTRUROIDES SCULPTURATUS EWING===
+
[https://www.uniprot.org/uniprot/SCXV_CENSC SCXV_CENSC] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.
-
 
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
<!--
+
Check<jmol>
-
The line below this paragraph, {{ABSTRACT_PUBMED_7739052}}, adds the Publication Abstract to the page
+
<jmolCheckbox>
-
(as it appears on PubMed at http://www.pubmed.gov), where 7739052 is the PubMed ID number.
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nr/1nra_consurf.spt"</scriptWhenChecked>
-
-->
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
{{ABSTRACT_PUBMED_7739052}}
+
<text>to colour the structure by Evolutionary Conservation</text>
-
 
+
</jmolCheckbox>
-
==About this Structure==
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nra ConSurf].
-
1NRA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Centruroides_sculpturatus Centruroides sculpturatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NRA OCA].
+
<div style="clear:both"></div>
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
Solution structure of an Old World-like neurotoxin from the venom of the New World scorpion Centruroides sculpturatus Ewing., Jablonsky MJ, Watt DD, Krishna NR, J Mol Biol. 1995 Apr 28;248(2):449-58. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7739052 7739052]
+
[[Category: Centruroides sculpturatus]]
[[Category: Centruroides sculpturatus]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Jablonsky, M J.]]
+
[[Category: Jablonsky MJ]]
-
[[Category: Krishna, N R.]]
+
[[Category: Krishna NR]]
-
[[Category: Neurotoxin]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:11:59 2008''
+

Current revision

SOLUTION STRUCTURE OF AN OLD WORLD-LIKE NEUROTOXIN FROM THE VENOM OF THE NEW WORLD SCORPION CENTRUROIDES SCULPTURATUS EWING

PDB ID 1nra

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nra"
Personal tools