1ntj

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{{Seed}}
 
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[[Image:1ntj.png|left|200px]]
 
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==Model of rat Crry determined by solution scattering, curve fitting and homology modelling==
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The line below this paragraph, containing "STRUCTURE_1ntj", creates the "Structure Box" on the page.
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<StructureSection load='1ntj' size='340' side='right'caption='[[1ntj]], [[Resolution|resolution]] 30.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ntj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NTJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray solution scattering, [[Resolution|Resolution]] 30&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ntj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ntj OCA], [https://pdbe.org/1ntj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ntj RCSB], [https://www.ebi.ac.uk/pdbsum/1ntj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ntj ProSAT]</span></td></tr>
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{{STRUCTURE_1ntj| PDB=1ntj | SCENE= }}
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</table>
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== Function ==
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===Model of rat Crry determined by solution scattering, curve fitting and homology modelling===
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[https://www.uniprot.org/uniprot/CR1L_RAT CR1L_RAT] Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Seems to act as a costimulatory factor for T-cells. May play a crucial role in early embryonic development by maintaining fetomaternal tolerance.<ref>PMID:15474557</ref> <ref>PMID:7534798</ref> <ref>PMID:8144902</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<!--
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_12767833}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 12767833 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/1ntj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_12767833}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ntj ConSurf].
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1NTJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTJ OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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The extended multidomain solution structures of the complement protein Crry and its chimeric conjugate Crry-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy., Aslam M, Guthridge JM, Hack BK, Quigg RJ, Holers VM, Perkins SJ, J Mol Biol. 2003 Jun 6;329(3):525-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12767833 12767833]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Aslam M]]
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[[Category: Aslam, M.]]
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[[Category: Guthridge JM]]
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[[Category: Guthridge, J M.]]
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[[Category: Hack BK]]
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[[Category: Hack, B K.]]
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[[Category: Holers VM]]
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[[Category: Holers, V M.]]
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[[Category: Perkins SJ]]
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[[Category: Perkins, S J.]]
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[[Category: Quigg RJ]]
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[[Category: Quigg, R J.]]
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[[Category: Ccp]]
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[[Category: Complement]]
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[[Category: Glycoprotein]]
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[[Category: Immunology]]
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[[Category: Repeat]]
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[[Category: Scr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:53:59 2008''
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Current revision

Model of rat Crry determined by solution scattering, curve fitting and homology modelling

PDB ID 1ntj

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