1y7n

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{{Seed}}
 
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[[Image:1y7n.png|left|200px]]
 
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==Solution structure of the second PDZ domain of the human neuronal adaptor X11alpha==
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The line below this paragraph, containing "STRUCTURE_1y7n", creates the "Structure Box" on the page.
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<StructureSection load='1y7n' size='340' side='right'caption='[[1y7n]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1y7n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y7N FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7n OCA], [https://pdbe.org/1y7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y7n RCSB], [https://www.ebi.ac.uk/pdbsum/1y7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7n ProSAT]</span></td></tr>
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{{STRUCTURE_1y7n| PDB=1y7n | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/APBA1_HUMAN APBA1_HUMAN] Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y7/1y7n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y7n ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Protection against reactive oxygen species is provided by the copper containing enzyme superoxide dismutase 1 (SOD1). The copper chaperone CCS is responsible for copper insertion into apo-SOD1. This role is impaired by an interaction between the second PDZ domain (PDZ2alpha) of the neuronal adaptor protein X11alpha and the third domain of CCS (McLoughlin et al. (2001) J. Biol. Chem., 276, 9303-9307). The solution structure of the PDZ2alpha domain has been determined and the interaction with peptides derived from CCS has been explored. PDZ2alpha binds to the last four amino acids of the CCS protein (PAHL) with a dissociation constant of 91 +/- 2 microM. Peptide variants have been used to map the interaction areas on PDZ2alpha for each amino acid, showing an important role for the C-terminal leucine, in line with canonical PDZ-peptide interactions.
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===Solution structure of the second PDZ domain of the human neuronal adaptor X11alpha===
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Solution structure of the second PDZ domain of the neuronal adaptor X11alpha and its interaction with the C-terminal peptide of the human copper chaperone for superoxide dismutase.,Duquesne AE, Ruijter M, Brouwer J, Drijfhout JW, Nabuurs SB, Spronk CA, Vuister GW, Ubbink M, Canters GW J Biomol NMR. 2005 Jul;32(3):209-18. PMID:16132821<ref>PMID:16132821</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16132821}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1y7n" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16132821 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16132821}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1Y7N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7N OCA].
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==Reference==
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Solution structure of the second PDZ domain of the neuronal adaptor X11alpha and its interaction with the C-terminal peptide of the human copper chaperone for superoxide dismutase., Duquesne AE, Ruijter M, Brouwer J, Drijfhout JW, Nabuurs SB, Spronk CA, Vuister GW, Ubbink M, Canters GW, J Biomol NMR. 2005 Jul;32(3):209-18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16132821 16132821]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Brouwer, J.]]
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[[Category: Brouwer J]]
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[[Category: Canters, G W.]]
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[[Category: Canters GW]]
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[[Category: Drijfhout, J W.]]
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[[Category: Drijfhout JW]]
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[[Category: Duquesne, A E.]]
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[[Category: Duquesne AE]]
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[[Category: Nabuurs, S B.]]
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[[Category: Nabuurs SB]]
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[[Category: Ruijter, M de.]]
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[[Category: Spronk CAEM]]
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[[Category: Spronk, C A.E M.]]
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[[Category: Ubbink M]]
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[[Category: Ubbink, M.]]
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[[Category: Vuister GW]]
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[[Category: Vuister, G W.]]
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[[Category: De Ruijter M]]
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[[Category: Copper chaperone for superoxide dismutase]]
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[[Category: Neuronal adaptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:08:36 2008''
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Current revision

Solution structure of the second PDZ domain of the human neuronal adaptor X11alpha

PDB ID 1y7n

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