1l2n

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(New page: 200px<br /><applet load="1l2n" size="450" color="white" frame="true" align="right" spinBox="true" caption="1l2n" /> '''Smt3 Solution Structure'''<br /> ==Overview...)
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[[Image:1l2n.jpg|left|200px]]<br /><applet load="1l2n" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1l2n" />
 
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'''Smt3 Solution Structure'''<br />
 
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==Overview==
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==Smt3 Solution Structure==
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Smt3 belongs to a growing family of ubiquitin-related proteins involved in, posttranslational protein modification. Independent studies demonstrate an, essential function of Smt3 in the regulation of nucleocytoplasmic, transport, and suggest a role in cell-cycle regulation. Here we report the, high-resolution NMR structure of yeast Smt3 in the complex free form. Our, comparison of the Smt3 NMR structure with the Smt3 crystal structure in, complex with the C-Terminal Ulp1 protease domain revealed large structural, differences in the binding surface, which is also involved in the, Smt3-Ubc-9 interaction detected by NMR. The structural differences in the, region indicate the important functions of conserved residues in less, structurally defined sequences.
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<StructureSection load='1l2n' size='340' side='right'caption='[[1l2n]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1l2n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L2N FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2n OCA], [https://pdbe.org/1l2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l2n RCSB], [https://www.ebi.ac.uk/pdbsum/1l2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l2n ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST] Not known; suppressor of MIF2 mutations.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/1l2n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l2n ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Smt3 belongs to a growing family of ubiquitin-related proteins involved in posttranslational protein modification. Independent studies demonstrate an essential function of Smt3 in the regulation of nucleocytoplasmic transport, and suggest a role in cell-cycle regulation. Here we report the high-resolution NMR structure of yeast Smt3 in the complex free form. Our comparison of the Smt3 NMR structure with the Smt3 crystal structure in complex with the C-Terminal Ulp1 protease domain revealed large structural differences in the binding surface, which is also involved in the Smt3-Ubc-9 interaction detected by NMR. The structural differences in the region indicate the important functions of conserved residues in less structurally defined sequences.
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==About this Structure==
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Solution structure of a yeast ubiquitin-like protein Smt3: the role of structurally less defined sequences in protein-protein recognitions.,Sheng W, Liao X Protein Sci. 2002 Jun;11(6):1482-91. PMID:12021447<ref>PMID:12021447</ref>
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1L2N is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1L2N OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Solution structure of a yeast ubiquitin-like protein Smt3: the role of structurally less defined sequences in protein-protein recognitions., Sheng W, Liao X, Protein Sci. 2002 Jun;11(6):1482-91. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12021447 12021447]
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</div>
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[[Category: Saccharomyces cerevisiae]]
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<div class="pdbe-citations 1l2n" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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[[Category: Liao, X.]]
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[[Category: Sheng, W.]]
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[[Category: nmr]]
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[[Category: smt3]]
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[[Category: structure]]
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[[Category: ubiquitin-like protein]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 20:11:40 2007''
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==See Also==
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*[[SUMO 3D Structures|SUMO 3D Structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Liao X]]
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[[Category: Sheng W]]

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Smt3 Solution Structure

PDB ID 1l2n

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