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1q7s

From Proteopedia

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{{Seed}}
 
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[[Image:1q7s.png|left|200px]]
 
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==Crystal structure of bit1==
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The line below this paragraph, containing "STRUCTURE_1q7s", creates the "Structure Box" on the page.
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<StructureSection load='1q7s' size='340' side='right'caption='[[1q7s]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1q7s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q7S FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q7s OCA], [https://pdbe.org/1q7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q7s RCSB], [https://www.ebi.ac.uk/pdbsum/1q7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q7s ProSAT]</span></td></tr>
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{{STRUCTURE_1q7s| PDB=1q7s | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of bit1===
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[https://www.uniprot.org/uniprot/PTH2_HUMAN PTH2_HUMAN] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).<ref>PMID:15006356</ref> Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.<ref>PMID:15006356</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<!--
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_14660562}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 14660562 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q7/1q7s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_14660562}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q7s ConSurf].
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1Q7S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7S OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity., De Pereda JM, Waas WF, Jan Y, Ruoslahti E, Schimmel P, Pascual J, J Biol Chem. 2004 Feb 27;279(9):8111-5. Epub 2003 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14660562 14660562]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Jan, Y.]]
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[[Category: De Pereda JM]]
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[[Category: Pascual, J.]]
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[[Category: Jan Y]]
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[[Category: Pereda, J M.De.]]
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[[Category: Pascual J]]
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[[Category: Ruoslahti, E.]]
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[[Category: Ruoslahti E]]
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[[Category: Schimmel, P.]]
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[[Category: Schimmel P]]
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[[Category: Waas, W F.]]
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[[Category: Waas WF]]
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[[Category: Apoptosis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:24:27 2008''
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Current revision

Crystal structure of bit1

PDB ID 1q7s

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