1u7m

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{{Seed}}
 
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[[Image:1u7m.png|left|200px]]
 
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==Solution structure of a diiron protein model: Due Ferri(II) turn mutant==
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The line below this paragraph, containing "STRUCTURE_1u7m", creates the "Structure Box" on the page.
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<StructureSection load='1u7m' size='340' side='right'caption='[[1u7m]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1u7m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U7M FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1u7m| PDB=1u7m | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u7m OCA], [https://pdbe.org/1u7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u7m RCSB], [https://www.ebi.ac.uk/pdbsum/1u7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u7m ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Although the analysis and design of turns that connect the strands in antiparallel beta-hairpins has reached an advanced state, much less is known concerning turns between antiparallel helices in helical hairpins. We have conducted an analysis of the structures and sequence preferences of two types of interhelical turns, each of which connects the two helices by a two-residue linker in an alphaL-beta conformation. Based on this analysis, it became apparent that the turn introduced into a designed four-helix bundle protein, DF1, did not occur within an optimal structural context. DF1 is a dimeric model for the diiron class of proteins. A longer loop with a beta-alphaR-beta conformation was inserted between two helices in the protein, and a sequence was chosen to stabilize its conformation. X-ray crystallography and NMR analysis of the protein showed the structure to be in excellent agreement with design.
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===Solution structure of a diiron protein model: Due Ferri(II) turn mutant===
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Analysis and design of turns in alpha-helical hairpins.,Lahr SJ, Engel DE, Stayrook SE, Maglio O, North B, Geremia S, Lombardi A, DeGrado WF J Mol Biol. 2005 Mar 11;346(5):1441-54. Epub 2005 Jan 13. PMID:15713492<ref>PMID:15713492</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15713492}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1u7m" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15713492 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15713492}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia coli]]
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U7M OCA].
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[[Category: Large Structures]]
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[[Category: Calhoun JR]]
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==Reference==
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[[Category: DeGrado WF]]
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Analysis and design of turns in alpha-helical hairpins., Lahr SJ, Engel DE, Stayrook SE, Maglio O, North B, Geremia S, Lombardi A, DeGrado WF, J Mol Biol. 2005 Mar 11;346(5):1441-54. Epub 2005 Jan 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15713492 15713492]
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[[Category: Lahr S]]
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[[Category: Lombardi A]]
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Proton and metal ion-dependent assembly of a model diiron protein., Pasternak A, Kaplan J, Lear JD, Degrado WF, Protein Sci. 2001 May;10(5):958-69. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11316876 11316876]
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[[Category: Maglio O]]
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[[Category: Nastri F]]
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Inaugural article: retrostructural analysis of metalloproteins: application to the design of a minimal model for diiron proteins., Lombardi A, Summa CM, Geremia S, Randaccio L, Pavone V, DeGrado WF, Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6298-305. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10841536 10841536]
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[[Category: Pavone V]]
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Preorganization of molecular binding sites in designed diiron proteins., Maglio O, Nastri F, Pavone V, Lombardi A, DeGrado WF, Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3772-7. Epub 2003 Mar 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12655072 12655072]
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[[Category: Calhoun, J R.]]
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[[Category: DeGrado, W F.]]
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[[Category: Lahr, S.]]
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[[Category: Lombardi, A.]]
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[[Category: Maglio, O.]]
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[[Category: Nastri, F.]]
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[[Category: Pavone, V.]]
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[[Category: Diiron protein]]
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[[Category: Four-helix bundle]]
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[[Category: Inter-helical loop]]
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[[Category: Protein design]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:34:38 2008''
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Current revision

Solution structure of a diiron protein model: Due Ferri(II) turn mutant

PDB ID 1u7m

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