2giy

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{{Seed}}
 
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[[Image:2giy.png|left|200px]]
 
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==Crystal Structure of the C-terminal domain of the HSV-1 gE ectodomain==
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The line below this paragraph, containing "STRUCTURE_2giy", creates the "Structure Box" on the page.
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<StructureSection load='2giy' size='340' side='right'caption='[[2giy]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2giy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_KOS Human alphaherpesvirus 1 strain KOS]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GIY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2giy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2giy OCA], [https://pdbe.org/2giy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2giy RCSB], [https://www.ebi.ac.uk/pdbsum/2giy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2giy ProSAT]</span></td></tr>
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{{STRUCTURE_2giy| PDB=2giy | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GE_HHV11 GE_HHV11] In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells (By similarity). In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips. The heterodimer gE/gI serves as a receptor for the Fc part of host IgG. Dissociation of gE/gI from IgG occurs at acidic pH. May thus be involved in anti-HSV antibodies bipolar bridging, followed by intracellular endocytosis and degradation, thereby interfering with host IgG-mediated immune responses.[https://www.uniprot.org/uniprot/Q703E9_HHV1 Q703E9_HHV1]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gi/2giy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2giy ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Herpes simplex virus type-1 expresses a heterodimeric Fc receptor, gE-gI, on the surfaces of virions and infected cells that binds the Fc region of host immunoglobulin G and is implicated in the cell-to-cell spread of virus. gE-gI binds immunoglobulin G at the basic pH of the cell surface and releases it at the acidic pH of lysosomes, consistent with a role in facilitating the degradation of antiviral antibodies. Here we identify the C-terminal domain of the gE ectodomain (CgE) as the minimal Fc-binding domain and present a 1.78-angstroms CgE structure. A 5-angstroms gE-gI/Fc crystal structure, which was independently verified by a theoretical prediction method, reveals that CgE binds Fc at the C(H)2-C(H)3 interface, the binding site for several mammalian and bacterial Fc-binding proteins. The structure identifies interface histidines that may confer pH-dependent binding and regions of CgE implicated in cell-to-cell spread of virus. The ternary organization of the gE-gI/Fc complex is compatible with antibody bipolar bridging, which can interfere with the antiviral immune response.
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===Crystal Structure of the C-terminal domain of the HSV-1 gE ectodomain===
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Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a mechanism for antibody bipolar bridging.,Sprague ER, Wang C, Baker D, Bjorkman PJ PLoS Biol. 2006 Jun;4(6):e148. Epub 2006 May 2. PMID:16646632<ref>PMID:16646632</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_16646632}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2giy" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16646632 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16646632}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Human alphaherpesvirus 1 strain KOS]]
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2GIY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIY OCA].
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[[Category: Large Structures]]
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[[Category: Baker D]]
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==Reference==
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[[Category: Bjorkman PJ]]
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Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a mechanism for antibody bipolar bridging., Sprague ER, Wang C, Baker D, Bjorkman PJ, PLoS Biol. 2006 Jun;4(6):e148. Epub 2006 May 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16646632 16646632]
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[[Category: Sprague ER]]
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[[Category: Human herpesvirus 1]]
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[[Category: Wang C]]
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[[Category: Single protein]]
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[[Category: Baker, D.]]
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[[Category: Bjorkman, P J.]]
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[[Category: Sprague, E R.]]
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[[Category: Wang, C.]]
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[[Category: Ig v domain]]
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[[Category: Viral fc receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:38:28 2008''
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Current revision

Crystal Structure of the C-terminal domain of the HSV-1 gE ectodomain

PDB ID 2giy

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