2d1x

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:45, 13 March 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2d1x.png|left|200px]]
 
-
<!--
+
==The crystal structure of the cortactin-SH3 domain and AMAP1-peptide complex==
-
The line below this paragraph, containing "STRUCTURE_2d1x", creates the "Structure Box" on the page.
+
<StructureSection load='2d1x' size='340' side='right'caption='[[2d1x]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2d1x]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D1X FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_2d1x| PDB=2d1x | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d1x OCA], [https://pdbe.org/2d1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d1x RCSB], [https://www.ebi.ac.uk/pdbsum/2d1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d1x ProSAT]</span></td></tr>
-
 
+
</table>
-
===The crystal structure of the cortactin-SH3 domain and AMAP1-peptide complex===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/SRC8_HUMAN SRC8_HUMAN] Contributes to the organization of the actin cytoskeleton and cell structure. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.<ref>PMID:21296879</ref> <ref>PMID:16636290</ref>
-
 
+
== Evolutionary Conservation ==
-
<!--
+
[[Image:Consurf_key_small.gif|200px|right]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_16636290}}, adds the Publication Abstract to the page
+
Check<jmol>
-
(as it appears on PubMed at http://www.pubmed.gov), where 16636290 is the PubMed ID number.
+
<jmolCheckbox>
-
-->
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d1/2d1x_consurf.spt"</scriptWhenChecked>
-
{{ABSTRACT_PUBMED_16636290}}
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
2D1X is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D1X OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d1x ConSurf].
-
 
+
<div style="clear:both"></div>
-
==Reference==
+
== References ==
-
Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis., Hashimoto S, Hirose M, Hashimoto A, Morishige M, Yamada A, Hosaka H, Akagi K, Ogawa E, Oneyama C, Agatsuma T, Okada M, Kobayashi H, Wada H, Nakano H, Ikegami T, Nakagawa A, Sabe H, Proc Natl Acad Sci U S A. 2006 May 2;103(18):7036-41. Epub 2006 Apr 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16636290 16636290]
+
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Protein complex]]
+
[[Category: Large Structures]]
-
[[Category: Agatsuma, T.]]
+
[[Category: Agatsuma T]]
-
[[Category: Akagi, K.]]
+
[[Category: Akagi K]]
-
[[Category: Hashimoto, A.]]
+
[[Category: Hashimoto A]]
-
[[Category: Hashimoto, S.]]
+
[[Category: Hashimoto S]]
-
[[Category: Hirose, M.]]
+
[[Category: Hirose M]]
-
[[Category: Hosaka, H.]]
+
[[Category: Hosaka H]]
-
[[Category: Ikegami, T.]]
+
[[Category: Ikegami T]]
-
[[Category: Kobayashi, H.]]
+
[[Category: Kobayashi H]]
-
[[Category: Morishige, M.]]
+
[[Category: Morishige M]]
-
[[Category: Nakagawa, A.]]
+
[[Category: Nakagawa A]]
-
[[Category: Nakano, H.]]
+
[[Category: Nakano H]]
-
[[Category: Ogawa, E.]]
+
[[Category: Ogawa E]]
-
[[Category: Okada, M.]]
+
[[Category: Okada M]]
-
[[Category: Oneyama, C.]]
+
[[Category: Oneyama C]]
-
[[Category: Sabe, H.]]
+
[[Category: Sabe H]]
-
[[Category: Wada, H.]]
+
[[Category: Wada H]]
-
[[Category: Yamada, A.]]
+
[[Category: Yamada A]]
-
[[Category: Complex]]
+
-
[[Category: Proline-rich]]
+
-
[[Category: Sh3]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:38:47 2008''
+

Current revision

The crystal structure of the cortactin-SH3 domain and AMAP1-peptide complex

PDB ID 2d1x

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2d1x"
Personal tools