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1r22

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{{Seed}}
 
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[[Image:1r22.png|left|200px]]
 
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==Crystal structure of the cyanobacterial metallothionein repressor SmtB (C14S/C61S/C121S mutant) in the Zn2alpha5-form==
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The line below this paragraph, containing "STRUCTURE_1r22", creates the "Structure Box" on the page.
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<StructureSection load='1r22' size='340' side='right'caption='[[1r22]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1r22]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechococcus_elongatus_PCC_7942_=_FACHB-805 Synechococcus elongatus PCC 7942 = FACHB-805]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R22 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R22 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1r22| PDB=1r22 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r22 OCA], [https://pdbe.org/1r22 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r22 RCSB], [https://www.ebi.ac.uk/pdbsum/1r22 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r22 ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the cyanobacterial metallothionein repressor SmtB (C14S/C61S/C121S mutant) in the Zn2alpha5-form===
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== Function ==
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[https://www.uniprot.org/uniprot/SMTB_SYNE7 SMTB_SYNE7] Transcriptional repressor of the expression of the smtA gene. Binds two zinc ions per dimer. The complex of DNA and SmtB is dissociated by zinc ions.<ref>PMID:12146943</ref> <ref>PMID:12407207</ref> <ref>PMID:8871549</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 14568530 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r2/1r22_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_14568530}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1R22 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Synechococcus_sp. Synechococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R22 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r22 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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A metal-ligand-mediated intersubunit allosteric switch in related SmtB/ArsR zinc sensor proteins., Eicken C, Pennella MA, Chen X, Koshlap KM, VanZile ML, Sacchettini JC, Giedroc DP, J Mol Biol. 2003 Oct 31;333(4):683-95. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14568530 14568530]
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<references/>
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[[Category: Single protein]]
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__TOC__
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[[Category: Synechococcus sp.]]
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</StructureSection>
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[[Category: Chen, X.]]
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[[Category: Large Structures]]
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[[Category: Eicken, C.]]
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[[Category: Synechococcus elongatus PCC 7942 = FACHB-805]]
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[[Category: Giedroc, D P.]]
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[[Category: Chen X]]
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[[Category: Koshlap, K M.]]
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[[Category: Eicken C]]
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[[Category: Pennella, M A.]]
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[[Category: Giedroc DP]]
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[[Category: Sacchettini, J C.]]
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[[Category: Koshlap KM]]
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[[Category: VanZile, M L.]]
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[[Category: Pennella MA]]
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[[Category: Dna binding protein]]
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[[Category: Sacchettini JC]]
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[[Category: Transcriptional regulation]]
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[[Category: VanZile ML]]
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[[Category: Winged hth protein]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:38:54 2008''
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Current revision

Crystal structure of the cyanobacterial metallothionein repressor SmtB (C14S/C61S/C121S mutant) in the Zn2alpha5-form

PDB ID 1r22

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