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1nsw

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{{Seed}}
 
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[[Image:1nsw.png|left|200px]]
 
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==The Crystal Structure of the K18G Mutant of the thioredoxin from Alicyclobacillus acidocaldarius==
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The line below this paragraph, containing "STRUCTURE_1nsw", creates the "Structure Box" on the page.
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<StructureSection load='1nsw' size='340' side='right'caption='[[1nsw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1nsw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NSW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nsw OCA], [https://pdbe.org/1nsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nsw RCSB], [https://www.ebi.ac.uk/pdbsum/1nsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nsw ProSAT]</span></td></tr>
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{{STRUCTURE_1nsw| PDB=1nsw | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/THIO_ALIAC THIO_ALIAC] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ns/1nsw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nsw ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report a crystallographic and computational analysis of two mutant forms of the Alicyclobacillus acidocaldarius thioredoxin (BacTrx) done in order to evaluate the contribution of two specific amino acids to the thermostability of BacTrx. Our results suggest that the thermostability of BacTrx may be modulated by mutations affecting the overall electrostatic energy of the protein.
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===The Crystal Structure of the K18G Mutant of the thioredoxin from Alicyclobacillus acidocaldarius===
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An integrated structural and computational study of the thermostability of two thioredoxin mutants from Alicyclobacillus acidocaldarius.,Bartolucci S, De Simone G, Galdiero S, Improta R, Menchise V, Pedone C, Pedone E, Saviano M J Bacteriol. 2003 Jul;185(14):4285-9. PMID:12837806<ref>PMID:12837806</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1nsw" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_12837806}}, adds the Publication Abstract to the page
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*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12837806 is the PubMed ID number.
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== References ==
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-->
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<references/>
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{{ABSTRACT_PUBMED_12837806}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1NSW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NSW OCA].
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==Reference==
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An integrated structural and computational study of the thermostability of two thioredoxin mutants from Alicyclobacillus acidocaldarius., Bartolucci S, De Simone G, Galdiero S, Improta R, Menchise V, Pedone C, Pedone E, Saviano M, J Bacteriol. 2003 Jul;185(14):4285-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12837806 12837806]
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[[Category: Alicyclobacillus acidocaldarius]]
[[Category: Alicyclobacillus acidocaldarius]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Thioredoxin-disulfide reductase]]
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[[Category: Bartolucci S]]
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[[Category: Bartolucci, S.]]
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[[Category: De Simone G]]
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[[Category: Galdiero, S.]]
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[[Category: Galdiero S]]
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[[Category: Improta, R.]]
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[[Category: Improta R]]
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[[Category: Menchise, V.]]
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[[Category: Menchise V]]
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[[Category: Pedone, C.]]
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[[Category: Pedone C]]
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[[Category: Pedone, E.]]
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[[Category: Pedone E]]
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[[Category: Saviano, M.]]
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[[Category: Saviano M]]
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[[Category: Simone, G De.]]
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[[Category: Thermostability]]
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[[Category: Thioredoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:43:09 2008''
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Current revision

The Crystal Structure of the K18G Mutant of the thioredoxin from Alicyclobacillus acidocaldarius

PDB ID 1nsw

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