1p8t

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{{Seed}}
 
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[[Image:1p8t.png|left|200px]]
 
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==Crystal structure of Nogo-66 Receptor==
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The line below this paragraph, containing "STRUCTURE_1p8t", creates the "Structure Box" on the page.
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<StructureSection load='1p8t' size='340' side='right'caption='[[1p8t]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1p8t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P8T FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
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{{STRUCTURE_1p8t| PDB=1p8t | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p8t OCA], [https://pdbe.org/1p8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p8t RCSB], [https://www.ebi.ac.uk/pdbsum/1p8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p8t ProSAT]</span></td></tr>
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</table>
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===Crystal structure of Nogo-66 Receptor===
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== Function ==
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[https://www.uniprot.org/uniprot/RTN4R_HUMAN RTN4R_HUMAN] Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development (By similarity).<ref>PMID:12037567</ref> <ref>PMID:14966521</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12839991 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p8/1p8t_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12839991}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1P8T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8T OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p8t ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins., Barton WA, Liu BP, Tzvetkova D, Jeffrey PD, Fournier AE, Sah D, Cate R, Strittmatter SM, Nikolov DB, EMBO J. 2003 Jul 1;22(13):3291-302. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12839991 12839991]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Barton, W A.]]
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[[Category: Barton WA]]
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[[Category: Cate, R.]]
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[[Category: Cate R]]
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[[Category: Fournier, A E.]]
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[[Category: Fournier AE]]
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[[Category: Jeffrey, P D.]]
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[[Category: Jeffrey PD]]
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[[Category: Liu, B P.]]
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[[Category: Liu BP]]
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[[Category: Nikolov, D B.]]
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[[Category: Nikolov DB]]
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[[Category: Sah, D.]]
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[[Category: Sah D]]
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[[Category: Strittmatter, S M.]]
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[[Category: Strittmatter SM]]
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[[Category: Tzvetkova, D.]]
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[[Category: Tzvetkova D]]
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[[Category: Ngr]]
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[[Category: Nogo-66]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:47:58 2008''
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Current revision

Crystal structure of Nogo-66 Receptor

PDB ID 1p8t

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OCA

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