2erb

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{{Seed}}
 
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[[Image:2erb.png|left|200px]]
 
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==AgamOBP1, and odorant binding protein from Anopheles gambiae complexed with PEG==
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The line below this paragraph, containing "STRUCTURE_2erb", creates the "Structure Box" on the page.
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<StructureSection load='2erb' size='340' side='right'caption='[[2erb]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2erb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ERB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEU:2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL'>PEU</scene></td></tr>
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{{STRUCTURE_2erb| PDB=2erb | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2erb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2erb OCA], [https://pdbe.org/2erb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2erb RCSB], [https://www.ebi.ac.uk/pdbsum/2erb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2erb ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/2erb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2erb ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Anopheles gambiae mosquito is the main vector of malaria transmission in sub-Saharan Africa. We present here a 1.5A crystal structure of AgamOBP1, an odorant binding protein (OBP) from the A. gambiae mosquito. The protein crystallized as a dimer with a unique binding pocket consisting of a continuous tunnel running through both subunits of the dimer and occupied by a PEG molecule. We demonstrate that AgamOBP1 undergoes a pH dependent conformational change that is associated with reduced ligand binding. A predominance of acid-labile hydrogen bonds involving the C-terminal loop suggests a mechanism in which a drop in pH causes C-terminal loop to open, leaving the binding tunnel solvent exposed, thereby lowering binding affinity for ligand. Because proteins from two distantly related insects also undergo a pH dependent conformational change involving the C-terminus that is associated with reduced ligand affinity, our results suggest a common mechanism for OBP activity.
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===AgamOBP1, and odorant binding protein from Anopheles gambiae complexed with PEG===
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The crystal structure of an odorant binding protein from Anopheles gambiae: evidence for a common ligand release mechanism.,Wogulis M, Morgan T, Ishida Y, Leal WS, Wilson DK Biochem Biophys Res Commun. 2006 Jan 6;339(1):157-64. Epub 2005 Nov 9. PMID:16300742<ref>PMID:16300742</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2erb" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_16300742}}, adds the Publication Abstract to the page
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*[[Odorant binding protein 3D structures|Odorant binding protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16300742 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16300742}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2ERB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERB OCA].
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==Reference==
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The crystal structure of an odorant binding protein from Anopheles gambiae: evidence for a common ligand release mechanism., Wogulis M, Morgan T, Ishida Y, Leal WS, Wilson DK, Biochem Biophys Res Commun. 2006 Jan 6;339(1):157-64. Epub 2005 Nov 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16300742 16300742]
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[[Category: Anopheles gambiae]]
[[Category: Anopheles gambiae]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ishida, Y.]]
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[[Category: Ishida Y]]
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[[Category: Leal, W S.]]
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[[Category: Leal WS]]
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[[Category: Morgan, T.]]
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[[Category: Morgan T]]
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[[Category: Wilson, D K.]]
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[[Category: Wilson DK]]
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[[Category: Wogulis, M.]]
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[[Category: Wogulis M]]
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[[Category: Disulfide]]
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[[Category: Helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:40:42 2008''
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Current revision

AgamOBP1, and odorant binding protein from Anopheles gambiae complexed with PEG

PDB ID 2erb

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