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1qrz

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{{Seed}}
 
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[[Image:1qrz.png|left|200px]]
 
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==CATALYTIC DOMAIN OF PLASMINOGEN==
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The line below this paragraph, containing "STRUCTURE_1qrz", creates the "Structure Box" on the page.
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<StructureSection load='1qrz' size='340' side='right'caption='[[1qrz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qrz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QRZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QRZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qrz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qrz OCA], [https://pdbe.org/1qrz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qrz RCSB], [https://www.ebi.ac.uk/pdbsum/1qrz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qrz ProSAT]</span></td></tr>
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{{STRUCTURE_1qrz| PDB=1qrz | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PLMN_HUMAN PLMN_HUMAN] Defects in PLG are the cause of plasminogen deficiency (PLGD) [MIM:[https://omim.org/entry/217090 217090]. PLGD is characterized by decreased serum plasminogen activity. Two forms of the disorder are distinguished: type 1 deficiency is additionally characterized by decreased plasminogen antigen levels and clinical symptoms, whereas type 2 deficiency, also known as dysplasminogenemia, is characterized by normal, or slightly reduced antigen levels, and absence of clinical manifestations. Plasminogen deficiency type 1 results in markedly impaired extracellular fibrinolysis and chronic mucosal pseudomembranous lesions due to subepithelial fibrin deposition and inflammation. The most common clinical manifestation of type 1 deficiency is ligneous conjunctivitis in which pseudomembranes formation on the palpebral surfaces of the eye progresses to white, yellow-white, or red thick masses with a wood-like consistency that replace the normal mucosa.<ref>PMID:1986355</ref> <ref>PMID:8392398</ref> <ref>PMID:6216475</ref> <ref>PMID:6238949</ref> <ref>PMID:1427790</ref> <ref>PMID:9242524</ref> <ref>PMID:9858247</ref> <ref>PMID:10233898</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/PLMN_HUMAN PLMN_HUMAN] Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.<ref>PMID:14699093</ref> Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.<ref>PMID:14699093</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qr/1qrz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qrz ConSurf].
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<div style="clear:both"></div>
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===CATALYTIC DOMAIN OF PLASMINOGEN===
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==See Also==
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*[[Plasminogen 3D structures|Plasminogen 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_10460175}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 10460175 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_10460175}}
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==About this Structure==
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1QRZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QRZ OCA].
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==Reference==
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Crystal structure of the proenzyme domain of plasminogen., Peisach E, Wang J, de los Santos T, Reich E, Ringe D, Biochemistry. 1999 Aug 24;38(34):11180-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10460175 10460175]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Peisach, E.]]
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[[Category: Peisach E]]
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[[Category: Reich, E.]]
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[[Category: Reich E]]
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[[Category: Ringe, D.]]
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[[Category: Ringe D]]
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[[Category: Santos, T de los.]]
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[[Category: Wang J]]
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[[Category: Wang, J.]]
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[[Category: De los Santos T]]
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[[Category: Chymotrypsin family]]
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[[Category: Microplasminogen]]
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[[Category: Serine protease]]
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[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:52:43 2008''
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Current revision

CATALYTIC DOMAIN OF PLASMINOGEN

PDB ID 1qrz

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