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1qdq

From Proteopedia

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{{Seed}}
 
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[[Image:1qdq.png|left|200px]]
 
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==X-RAY CRYSTAL STRUCTURE OF BOVINE CATHEPSIN B-CA074 COMPLEX==
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The line below this paragraph, containing "STRUCTURE_1qdq", creates the "Structure Box" on the page.
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<StructureSection load='1qdq' size='340' side='right'caption='[[1qdq]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qdq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QDQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QDQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=074:[PROPYLAMINO-3-HYDROXY-BUTAN-1,4-DIONYL]-ISOLEUCYL-PROLINE'>074</scene></td></tr>
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{{STRUCTURE_1qdq| PDB=1qdq | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qdq OCA], [https://pdbe.org/1qdq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qdq RCSB], [https://www.ebi.ac.uk/pdbsum/1qdq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qdq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CATB_BOVIN CATB_BOVIN] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qd/1qdq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qdq ConSurf].
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<div style="clear:both"></div>
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===X-RAY CRYSTAL STRUCTURE OF BOVINE CATHEPSIN B-CA074 COMPLEX===
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==See Also==
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_10739956}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10739956 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10739956}}
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==About this Structure==
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1QDQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QDQ OCA].
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==Reference==
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Substrate specificity of bovine cathepsin B and its inhibition by CA074, based on crystal structure refinement of the complex., Yamamoto A, Tomoo K, Hara T, Murata M, Kitamura K, Ishida T, J Biochem. 2000 Apr;127(4):635-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10739956 10739956]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Cathepsin B]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Yamamoto A]]
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[[Category: Yamamoto, A.]]
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[[Category: Cathepsin b]]
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[[Category: Cathepsin b-specific inhibitor complex]]
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[[Category: Papain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:53:21 2008''
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Current revision

X-RAY CRYSTAL STRUCTURE OF BOVINE CATHEPSIN B-CA074 COMPLEX

PDB ID 1qdq

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