1lau

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(New page: 200px<br /><applet load="1lau" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lau, resolution 1.800&Aring;" /> '''URACIL-DNA GLYCOSYL...)
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[[Image:1lau.jpg|left|200px]]<br /><applet load="1lau" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1lau, resolution 1.800&Aring;" />
 
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'''URACIL-DNA GLYCOSYLASE'''<br />
 
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==Overview==
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==URACIL-DNA GLYCOSYLASE==
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The 1.75-A crystal structure of the uracil-DNA glycosylase from herpes, simplex virus type-1 reveals a new fold, distantly related to, dinucleotide-binding proteins. Complexes with a trideoxynucleotide, and, with uracil, define the DNA-binding site and allow a detailed, understanding of the exquisitely specific recognition of uracil in DNA., The overall structure suggests binding models for elongated single- and, double-stranded DNA substrates. Conserved residues close to the, uracil-binding site suggest a catalytic mechanism for hydrolytic base, excision.
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<StructureSection load='1lau' size='340' side='right'caption='[[1lau]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1lau]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1 Human alphaherpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LAU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lau OCA], [https://pdbe.org/1lau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lau RCSB], [https://www.ebi.ac.uk/pdbsum/1lau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lau ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UNG_HHV11 UNG_HHV11] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosine. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly, in terminally differentiated neurons which lack DNA repair enzymes.<ref>PMID:7552746</ref> <ref>PMID:16306042</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/la/1lau_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lau ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1LAU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1LAU OCA].
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*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
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== References ==
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==Reference==
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<references/>
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The structural basis of specific base-excision repair by uracil-DNA glycosylase., Savva R, McAuley-Hecht K, Brown T, Pearl L, Nature. 1995 Feb 9;373(6514):487-93. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7845459 7845459]
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__TOC__
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[[Category: Human herpesvirus 4]]
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</StructureSection>
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[[Category: Single protein]]
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[[Category: Human alphaherpesvirus 1]]
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[[Category: Pearl, L.H.]]
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[[Category: Large Structures]]
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[[Category: Savva, R.]]
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[[Category: Pearl LH]]
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[[Category: dna]]
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[[Category: Savva R]]
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[[Category: glycosidase]]
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[[Category: hydrolase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 20:26:04 2007''
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Current revision

URACIL-DNA GLYCOSYLASE

PDB ID 1lau

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