2aa7

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{{Seed}}
 
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[[Image:2aa7.png|left|200px]]
 
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==Mineralocorticoid Receptor with Bound Deoxycorticosterone==
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The line below this paragraph, containing "STRUCTURE_2aa7", creates the "Structure Box" on the page.
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<StructureSection load='2aa7' size='340' side='right'caption='[[2aa7]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2aa7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AA7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AA7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CA:DESOXYCORTICOSTERONE'>1CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2aa7| PDB=2aa7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aa7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aa7 OCA], [https://pdbe.org/2aa7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aa7 RCSB], [https://www.ebi.ac.uk/pdbsum/2aa7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aa7 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MCR_HUMAN MCR_HUMAN] Defects in NR3C2 are a cause of pseudohypoaldosteronism 1, autosomal dominant (PHA1A) [MIM:[https://omim.org/entry/177735 177735]. A salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. PHA1A is a mild form characterized by target organ defects confined to kidney. Patients may present with neonatal renal salt wasting with hyperkalaemic acidosis despite high aldosterone levels. These patients improve with age and usually become asymptomatic without treatment.<ref>PMID:9662404</ref> <ref>PMID:11134129</ref> <ref>PMID:12788847</ref> <ref>PMID:16954160</ref> <ref>PMID:16972228</ref> Defects in NR3C2 are a cause of early-onset hypertension with severe exacerbation in pregnancy (EOHSEP) [MIM:[https://omim.org/entry/605115 605115]. Inheritance is autosomal dominant. The disease is characterized by the onset of severe hypertension before the age of 20, and by suppression of aldosterone secretion.<ref>PMID:9662404</ref> <ref>PMID:15967794</ref> <ref>PMID:15908963</ref> <ref>PMID:10884226</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/MCR_HUMAN MCR_HUMAN] Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.<ref>PMID:3037703</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aa/2aa7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aa7 ConSurf].
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<div style="clear:both"></div>
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===Mineralocorticoid Receptor with Bound Deoxycorticosterone===
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==See Also==
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*[[Mineralocorticoid receptor|Mineralocorticoid receptor]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_15967794}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 15967794 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_15967794}}
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==About this Structure==
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2AA7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AA7 OCA].
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==Reference==
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A ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptor., Bledsoe RK, Madauss KP, Holt JA, Apolito CJ, Lambert MH, Pearce KH, Stanley TB, Stewart EL, Trump RP, Willson TM, Williams SP, J Biol Chem. 2005 Sep 2;280(35):31283-93. Epub 2005 Jun 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15967794 15967794]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Apolito, C J.]]
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[[Category: Apolito CJ]]
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[[Category: Bledsoe, R K.]]
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[[Category: Bledsoe RK]]
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[[Category: Holt, J A.]]
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[[Category: Holt JA]]
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[[Category: Lambert, M H.]]
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[[Category: Lambert MH]]
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[[Category: Madauss, K P.]]
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[[Category: Madauss KP]]
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[[Category: Pearce, K H.]]
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[[Category: Pearce KH]]
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[[Category: Stanley, T B.]]
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[[Category: Stanley TB]]
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[[Category: Stewart, E L.]]
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[[Category: Stewart EL]]
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[[Category: Trump, R P.]]
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[[Category: Trump RP]]
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[[Category: Williams, S P.]]
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[[Category: Williams SP]]
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[[Category: Willson, T M.]]
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[[Category: Willson TM]]
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[[Category: Deoxycorticosterone]]
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[[Category: Hypertension]]
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[[Category: Mineralocorticoid receptor]]
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[[Category: Mr]]
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[[Category: Nuclear receptor]]
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[[Category: Steroid receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:01:35 2008''
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Current revision

Mineralocorticoid Receptor with Bound Deoxycorticosterone

PDB ID 2aa7

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