2jug

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{{Seed}}
 
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[[Image:2jug.png|left|200px]]
 
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==Multienzyme Docking in Hybrid Megasynthetases==
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The line below this paragraph, containing "STRUCTURE_2jug", creates the "Structure Box" on the page.
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<StructureSection load='2jug' size='340' side='right'caption='[[2jug]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Archangium_disciforme Archangium disciforme]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JUG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jug OCA], [https://pdbe.org/2jug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jug RCSB], [https://www.ebi.ac.uk/pdbsum/2jug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jug ProSAT]</span></td></tr>
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{{STRUCTURE_2jug| PDB=2jug | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q5ZPA9_9BACT Q5ZPA9_9BACT]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/2jug_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jug ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Hybrid multienzyme systems composed of polyketide synthase (PKS) and nonribosomal polypeptide synthetase (NRPS) modules direct the biosynthesis of clinically valuable natural products in bacteria. The fidelity of this process depends on specific recognition between successive polypeptides in each assembly line-interactions that are mediated by terminal 'docking domains'. We have identified a new family of N-terminal docking domains, exemplified by TubCdd from the tubulysin system of Angiococcus disciformis An d48. TubCdd is homodimeric, which suggests that NRPS subunits in mixed systems self-associate to interact with partner PKS homodimers. The NMR structure of TubCdd reveals a new fold featuring an exposed beta-hairpin that serves as the binding site for the C-terminal docking domain of the partner polypeptide. The pattern of charged residues on the contact surface of the beta-hairpin is a key determinant of the interaction and seems to constitute a 'docking code' that can be used to alter binding affinity.
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===Multienzyme Docking in Hybrid Megasynthetases===
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Multienzyme docking in hybrid megasynthetases.,Richter CD, Nietlispach D, Broadhurst RW, Weissman KJ Nat Chem Biol. 2008 Jan;4(1):75-81. Epub 2007 Dec 9. PMID:18066054<ref>PMID:18066054</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18066054}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2jug" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18066054 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18066054}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Archangium disciforme]]
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2JUG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Angiococcus_disciformis Angiococcus disciformis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUG OCA].
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[[Category: Large Structures]]
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[[Category: Broadhurst RW]]
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==Reference==
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[[Category: Nietlispach D]]
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Multienzyme docking in hybrid megasynthetases., Richter CD, Nietlispach D, Broadhurst RW, Weissman KJ, Nat Chem Biol. 2008 Jan;4(1):75-81. Epub 2007 Dec 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18066054 18066054]
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[[Category: Richter CD]]
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[[Category: Angiococcus disciformis]]
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[[Category: Weissman KJ]]
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[[Category: Single protein]]
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[[Category: Broadhurst, R W.]]
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[[Category: Nietlispach, D.]]
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[[Category: Richter, C D.]]
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[[Category: Weissman, K J.]]
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[[Category: Biosynthetic protein]]
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[[Category: Dimer]]
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[[Category: Docking domain]]
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[[Category: Ligase]]
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[[Category: Nonribosomal peptide synthetase]]
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[[Category: Phosphopantetheine]]
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[[Category: Tubulysin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:07:32 2008''
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Current revision

Multienzyme Docking in Hybrid Megasynthetases

PDB ID 2jug

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