1ldg

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(New page: 200px<br /><applet load="1ldg" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ldg, resolution 1.74&Aring;" /> '''PLASMODIUM FALCIPARU...)
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[[Image:1ldg.gif|left|200px]]<br /><applet load="1ldg" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1ldg, resolution 1.74&Aring;" />
 
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'''PLASMODIUM FALCIPARUM L-LACTATE DEHYDROGENASE COMPLEXED WITH NADH AND OXAMATE'''<br />
 
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==About this Structure==
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==PLASMODIUM FALCIPARUM L-LACTATE DEHYDROGENASE COMPLEXED WITH NADH AND OXAMATE==
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1LDG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum] with NAD and OXM as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1LDG OCA].
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<StructureSection load='1ldg' size='340' side='right'caption='[[1ldg]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ldg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LDG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LDG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=OXM:OXAMIC+ACID'>OXM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ldg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ldg OCA], [https://pdbe.org/1ldg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ldg RCSB], [https://www.ebi.ac.uk/pdbsum/1ldg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ldg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LDH_PLAFD LDH_PLAFD]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ld/1ldg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ldg ConSurf].
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<div style="clear:both"></div>
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==Reference==
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==See Also==
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The structure of lactate dehydrogenase from Plasmodium falciparum reveals a new target for anti-malarial design., Dunn CR, Banfield MJ, Barker JJ, Higham CW, Moreton KM, Turgut-Balik D, Brady RL, Holbrook JJ, Nat Struct Biol. 1996 Nov;3(11):912-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8901865 8901865]
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*[[Lactate dehydrogenase 3D structures|Lactate dehydrogenase 3D structures]]
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[[Category: L-lactate dehydrogenase]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
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[[Category: Single protein]]
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[[Category: Banfield M]]
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[[Category: Banfield, M.]]
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[[Category: Barker J]]
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[[Category: Barker, J.]]
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[[Category: Brady L]]
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[[Category: Brady, L.]]
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[[Category: Dunn C]]
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[[Category: Dunn, C.]]
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[[Category: Higham C]]
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[[Category: Higham, C.]]
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[[Category: Holbrook JJ]]
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[[Category: Holbrook, J.J.]]
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[[Category: Moreton K]]
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[[Category: Moreton, K.]]
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[[Category: Turgut-Balik D]]
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[[Category: Turgut-Balik, D.]]
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[[Category: NAD]]
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[[Category: OXM]]
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[[Category: nad]]
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[[Category: oxidoreductase]]
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[[Category: tricarboxylic acid cycle]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 20:30:02 2007''
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Current revision

PLASMODIUM FALCIPARUM L-LACTATE DEHYDROGENASE COMPLEXED WITH NADH AND OXAMATE

PDB ID 1ldg

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