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1tff

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{{Seed}}
 
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[[Image:1tff.png|left|200px]]
 
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<!--
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==Structure of Otubain-2==
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The line below this paragraph, containing "STRUCTURE_1tff", creates the "Structure Box" on the page.
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<StructureSection load='1tff' size='340' side='right'caption='[[1tff]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tff]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TFF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1tff| PDB=1tff | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tff OCA], [https://pdbe.org/1tff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tff RCSB], [https://www.ebi.ac.uk/pdbsum/1tff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tff ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OTUB2_HUMAN OTUB2_HUMAN] Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.<ref>PMID:12704427</ref> <ref>PMID:18954305</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tf/1tff_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tff ConSurf].
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<div style="clear:both"></div>
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===Structure of Otubain-2===
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==See Also==
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*[[Thioesterase 3D structures|Thioesterase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_15258613}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 15258613 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_15258613}}
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==About this Structure==
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1TFF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TFF OCA].
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==Reference==
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Crystal structure of human otubain 2., Nanao MH, Tcherniuk SO, Chroboczek J, Dideberg O, Dessen A, Balakirev MY, EMBO Rep. 2004 Aug;5(8):783-8. Epub 2004 Jul 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15258613 15258613]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Balakirev, M Y.]]
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[[Category: Balakirev MY]]
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[[Category: Chroboczek, J.]]
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[[Category: Chroboczek J]]
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[[Category: Dessen, A.]]
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[[Category: Dessen A]]
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[[Category: Dideberg, O.]]
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[[Category: Dideberg O]]
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[[Category: Nanao, M H.]]
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[[Category: Nanao MH]]
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[[Category: Tcherniuk, S O.]]
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[[Category: Tcherniuk SO]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:26:31 2008''
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Current revision

Structure of Otubain-2

PDB ID 1tff

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