2csd

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{{Seed}}
 
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[[Image:2csd.png|left|200px]]
 
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==Crystal structure of Topoisomerase V (61 kDa fragment)==
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The line below this paragraph, containing "STRUCTURE_2csd", creates the "Structure Box" on the page.
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<StructureSection load='2csd' size='340' side='right'caption='[[2csd]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2csd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanopyrus_kandleri Methanopyrus kandleri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CSD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2csd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csd OCA], [https://pdbe.org/2csd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2csd RCSB], [https://www.ebi.ac.uk/pdbsum/2csd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2csd ProSAT]</span></td></tr>
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{{STRUCTURE_2csd| PDB=2csd | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q977W1_9EURY Q977W1_9EURY]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Topoisomerases are involved in controlling and maintaining the topology of DNA and are present in all kingdoms of life. Unlike all other types of topoisomerases, similar type IB enzymes have only been identified in bacteria and eukarya. The only putative type IB topoisomerase in archaea is represented by Methanopyrus kandleri topoisomerase V. Despite several common functional characteristics, topoisomerase V shows no sequence similarity to other members of the same type. The structure of the 61 kDa N-terminal fragment of topoisomerase V reveals no structural similarity to other topoisomerases. Furthermore, the structure of the active site region is different, suggesting no conservation in the cleavage and religation mechanism. Additionally, the active site is buried, indicating the need of a conformational change for activity. The presence of a topoisomerase in archaea with a unique structure suggests the evolution of a separate mechanism to alter DNA.
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===Crystal structure of Topoisomerase V (61 kDa fragment)===
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Structure of the N-terminal fragment of topoisomerase V reveals a new family of topoisomerases.,Taneja B, Patel A, Slesarev A, Mondragon A EMBO J. 2006 Jan 25;25(2):398-408. Epub 2006 Jan 5. PMID:16395333<ref>PMID:16395333</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2csd" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_16395333}}, adds the Publication Abstract to the page
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*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16395333 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16395333}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2CSD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanopyrus_kandleri Methanopyrus kandleri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSD OCA].
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==Reference==
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Structure of the N-terminal fragment of topoisomerase V reveals a new family of topoisomerases., Taneja B, Patel A, Slesarev A, Mondragon A, EMBO J. 2006 Jan 25;25(2):398-408. Epub 2006 Jan 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16395333 16395333]
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[[Category: Methanopyrus kandleri]]
[[Category: Methanopyrus kandleri]]
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[[Category: Single protein]]
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[[Category: Mondragon A]]
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[[Category: Mondragon, A.]]
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[[Category: Patel A]]
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[[Category: Patel, A.]]
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[[Category: Slesarev A]]
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[[Category: Slesarev, A.]]
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[[Category: Taneja B]]
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[[Category: Taneja, B.]]
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[[Category: Helix-hairpin-helix]]
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[[Category: Helix-turn-helix]]
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[[Category: Hhh motif]]
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[[Category: Three helix bundle]]
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[[Category: Topoisomerase ib]]
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[[Category: Topoisomerase v]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:27:10 2008''
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Current revision

Crystal structure of Topoisomerase V (61 kDa fragment)

PDB ID 2csd

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