3aky

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{{Seed}}
 
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[[Image:3aky.png|left|200px]]
 
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==STABILITY, ACTIVITY AND STRUCTURE OF ADENYLATE KINASE MUTANTS==
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The line below this paragraph, containing "STRUCTURE_3aky", creates the "Structure Box" on the page.
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<StructureSection load='3aky' size='340' side='right'caption='[[3aky]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3aky]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AKY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AP5:BIS(ADENOSINE)-5-PENTAPHOSPHATE'>AP5</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
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{{STRUCTURE_3aky| PDB=3aky | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aky OCA], [https://pdbe.org/3aky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aky RCSB], [https://www.ebi.ac.uk/pdbsum/3aky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aky ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KAD2_YEAST KAD2_YEAST] Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.[HAMAP-Rule:MF_03168]<ref>PMID:18433446</ref> <ref>PMID:2848829</ref> <ref>PMID:2850178</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ak/3aky_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3aky ConSurf].
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<div style="clear:both"></div>
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===STABILITY, ACTIVITY AND STRUCTURE OF ADENYLATE KINASE MUTANTS===
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==See Also==
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*[[Adenylate kinase 3D structures|Adenylate kinase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 7635152 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_7635152}}
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==About this Structure==
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3AKY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AKY OCA].
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==Reference==
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Stability, activity and structure of adenylate kinase mutants., Spuergin P, Abele U, Schulz GE, Eur J Biochem. 1995 Jul 15;231(2):405-13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7635152 7635152]
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[[Category: Adenylate kinase]]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Abele U]]
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[[Category: Abele, U.]]
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[[Category: Schulz GE]]
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[[Category: Schulz, G E.]]
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[[Category: Atp:amp phosphotransferase]]
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[[Category: Myokinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:34:35 2008''
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Current revision

STABILITY, ACTIVITY AND STRUCTURE OF ADENYLATE KINASE MUTANTS

PDB ID 3aky

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