1lfp

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(New page: 200px<br /><applet load="1lfp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lfp, resolution 1.72&Aring;" /> '''Crystal Structure of...)
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[[Image:1lfp.gif|left|200px]]<br /><applet load="1lfp" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1lfp, resolution 1.72&Aring;" />
 
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'''Crystal Structure of a Conserved Hypothetical Protein Aq1575 from Aquifex Aeolicus'''<br />
 
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==Overview==
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==Crystal Structure of a Conserved Hypothetical Protein Aq1575 from Aquifex Aeolicus==
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The crystal structure of a conserved hypothetical protein, Aq1575, from, Aquifex aeolicus has been determined by using x-ray crystallography. The, protein belongs to the domain of unknown function DUF28 in the Pfam and, PALI databases for which there was no structural information available, until now. A structural homology search with the DALI algorithm indicates, that this protein has a new fold with no obvious similarity to those of, other proteins of known three-dimensional structure. The protein reveals a, monomer consisting of three domains arranged along a pseudo threefold, symmetry axis. There is a large cleft with approximate dimensions of 10 A, x 10 A x 20 A in the center of the three domains along the symmetry axis., Two possible active sites are suggested based on the structure and, multiple sequence alignment. There are several highly conserved residues, in these putative active sites. The structure based molecular properties, and thermostability of the protein are discussed.
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<StructureSection load='1lfp' size='340' side='right'caption='[[1lfp]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1lfp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LFP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lfp OCA], [https://pdbe.org/1lfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lfp RCSB], [https://www.ebi.ac.uk/pdbsum/1lfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lfp ProSAT], [https://www.topsan.org/Proteins/BSGC/1lfp TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Y1575_AQUAE Y1575_AQUAE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lf/1lfp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lfp ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of a conserved hypothetical protein, Aq1575, from Aquifex aeolicus has been determined by using x-ray crystallography. The protein belongs to the domain of unknown function DUF28 in the Pfam and PALI databases for which there was no structural information available until now. A structural homology search with the DALI algorithm indicates that this protein has a new fold with no obvious similarity to those of other proteins of known three-dimensional structure. The protein reveals a monomer consisting of three domains arranged along a pseudo threefold symmetry axis. There is a large cleft with approximate dimensions of 10 A x 10 A x 20 A in the center of the three domains along the symmetry axis. Two possible active sites are suggested based on the structure and multiple sequence alignment. There are several highly conserved residues in these putative active sites. The structure based molecular properties and thermostability of the protein are discussed.
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==About this Structure==
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Crystal structure of conserved hypothetical protein Aq1575 from Aquifex aeolicus.,Shin DH, Yokota H, Kim R, Kim SH Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7980-5. PMID:12060744<ref>PMID:12060744</ref>
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1LFP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1LFP OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Crystal structure of conserved hypothetical protein Aq1575 from Aquifex aeolicus., Shin DH, Yokota H, Kim R, Kim SH, Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7980-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12060744 12060744]
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</div>
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<div class="pdbe-citations 1lfp" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Aquifex aeolicus]]
[[Category: Aquifex aeolicus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: BSGC, Berkeley.Structural.Genomics.Center.]]
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[[Category: Kim R]]
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[[Category: Kim, R.]]
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[[Category: Kim SH]]
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[[Category: Kim, S.H.]]
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[[Category: Shin DH]]
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[[Category: Shin, D.H.]]
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[[Category: Yokota H]]
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[[Category: Yokota, H.]]
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[[Category: berkeley structural genomics center]]
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[[Category: bsgc structure funded by nih]]
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[[Category: hypothetical]]
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[[Category: new fold]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomics]]
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[[Category: thermostability]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 20:32:10 2007''
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Current revision

Crystal Structure of a Conserved Hypothetical Protein Aq1575 from Aquifex Aeolicus

PDB ID 1lfp

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