1lhs

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(New page: 200px<br /><applet load="1lhs" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lhs, resolution 2.0&Aring;" /> '''LOGGERHEAD SEA TURTLE...)
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[[Image:1lhs.jpg|left|200px]]<br /><applet load="1lhs" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1lhs, resolution 2.0&Aring;" />
 
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'''LOGGERHEAD SEA TURTLE MYOGLOBIN (AQUO-MET)'''<br />
 
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==Overview==
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==LOGGERHEAD SEA TURTLE MYOGLOBIN (AQUO-MET)==
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The X-ray crystal structures of the aquo-met and cyano-met derivatives of, the loggerhead sea turtle (Caretta caretta) myoglobin have been determined, at 2.0 A resolution (R = 0.182, and 0.178, respectively). The results here, reported, representing the first reptile globin solved by X-ray, crystallography, have been analyzed in parallel with data for related, monomeric hemoproteins, and indicate a strong overall structural, similarity between the loggerhead sea turtle and mammalian myoglobins, reflected by the 63% amino acid identity of their primary structures. The, root-mean-square deviation between the entire polypeptide backbones of, loggerhead sea turtle and sperm whale myoglobins, after structure, superposition, is 0.83 A. Upon cyanide binding to the protein distal site, the iron-bound water molecule present in the aquo-met form is displaced by, the incoming ligand. Cyanide is oriented towards the inner part of the, heme distal site forming a Fe-C-N angle of 133 degrees.
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<StructureSection load='1lhs' size='340' side='right'caption='[[1lhs]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1lhs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caretta_caretta Caretta caretta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LHS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lhs OCA], [https://pdbe.org/1lhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lhs RCSB], [https://www.ebi.ac.uk/pdbsum/1lhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lhs ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MYG_CARCR MYG_CARCR] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lh/1lhs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lhs ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1LHS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Caretta_caretta Caretta caretta] with HEM as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1LHS OCA].
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*[[Myoglobin 3D structures|Myoglobin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Reptile heme protein structure: X-ray crystallographic study of the aquo-met and cyano-met derivatives of the loggerhead sea turtle (Caretta caretta) myoglobin at 2.0 A resolution., Nardini M, Tarricone C, Rizzi M, Lania A, Desideri A, De Sanctis G, Coletta M, Petruzzelli R, Ascenzi P, Coda A, et al., J Mol Biol. 1995 Mar 31;247(3):459-65. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7714901 7714901]
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[[Category: Caretta caretta]]
[[Category: Caretta caretta]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ascenzi, P.]]
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[[Category: Ascenzi P]]
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[[Category: Bolognesi, M.]]
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[[Category: Bolognesi M]]
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[[Category: Coda, A.]]
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[[Category: Coda A]]
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[[Category: Coletta, M.]]
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[[Category: Coletta M]]
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[[Category: Desideri, A.]]
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[[Category: De Sanctis G]]
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[[Category: Lania, A.]]
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[[Category: Desideri A]]
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[[Category: Nardini, M.]]
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[[Category: Lania A]]
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[[Category: Petruzzelli, R.]]
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[[Category: Nardini M]]
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[[Category: Sanctis, G.De.]]
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[[Category: Petruzzelli R]]
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[[Category: Tarricone, C.]]
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[[Category: Tarricone C]]
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[[Category: HEM]]
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[[Category: oxygen storage]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 20:33:58 2007''
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Current revision

LOGGERHEAD SEA TURTLE MYOGLOBIN (AQUO-MET)

PDB ID 1lhs

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