1w8k

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{{Seed}}
 
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[[Image:1w8k.png|left|200px]]
 
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==Crystal structure of apical membrane antigen 1 from Plasmodium vivax==
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The line below this paragraph, containing "STRUCTURE_1w8k", creates the "Structure Box" on the page.
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<StructureSection load='1w8k' size='340' side='right'caption='[[1w8k]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1w8k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W8K FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
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{{STRUCTURE_1w8k| PDB=1w8k | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w8k OCA], [https://pdbe.org/1w8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w8k RCSB], [https://www.ebi.ac.uk/pdbsum/1w8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w8k ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O61130_PLAVI O61130_PLAVI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w8/1w8k_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w8k ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Apical membrane antigen 1 from Plasmodium is a leading malaria vaccine candidate. The protein is essential for host-cell invasion, but its molecular function is unknown. The crystal structure of the three domains comprising the ectoplasmic region of the antigen from P. vivax, solved at 1.8 angstrom resolution, shows that domains I and II belong to the PAN motif, which defines a superfamily of protein folds implicated in receptor binding. We also mapped the epitope of an invasion-inhibitory monoclonal antibody specific for the P. falciparum ortholog and modeled this to the structure. The location of the epitope and current knowledge on structure-function correlations for PAN domains together suggest a receptor-binding role during invasion in which domain II plays a critical part. These results are likely to aid vaccine and drug design.
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===CRYSTAL STRUCTURE OF APICAL MEMBRANE ANTIGEN 1 FROM PLASMODIUM VIVAX===
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Crystal structure of the malaria vaccine candidate apical membrane antigen 1.,Pizarro JC, Vulliez-Le Normand B, Chesne-Seck ML, Collins CR, Withers-Martinez C, Hackett F, Blackman MJ, Faber BW, Remarque EJ, Kocken CH, Thomas AW, Bentley GA Science. 2005 Apr 15;308(5720):408-11. Epub 2005 Feb 24. PMID:15731407<ref>PMID:15731407</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15731407}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1w8k" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15731407 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15731407}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1W8K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W8K OCA].
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==Reference==
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Crystal structure of the malaria vaccine candidate apical membrane antigen 1., Pizarro JC, Vulliez-Le Normand B, Chesne-Seck ML, Collins CR, Withers-Martinez C, Hackett F, Blackman MJ, Faber BW, Remarque EJ, Kocken CH, Thomas AW, Bentley GA, Science. 2005 Apr 15;308(5720):408-11. Epub 2005 Feb 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15731407 15731407]
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[[Category: Plasmodium vivax]]
[[Category: Plasmodium vivax]]
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[[Category: Single protein]]
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[[Category: Bentley GA]]
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[[Category: Bentley, G A.]]
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[[Category: Chesne-Seck M-L]]
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[[Category: Chesne-Seck, M L.]]
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[[Category: Kocken CHM]]
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[[Category: Kocken, C H.M.]]
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[[Category: Pizarro JC]]
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[[Category: Normand, B Vulliez-Le.]]
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[[Category: Thomas AW]]
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[[Category: Pizarro, J C.]]
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[[Category: Vulliez-Le Normand B]]
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[[Category: Thomas, A W.]]
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[[Category: Antigen]]
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[[Category: Malaria vaccine candidate]]
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[[Category: Plasmodium antigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:00:25 2008''
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Current revision

Crystal structure of apical membrane antigen 1 from Plasmodium vivax

PDB ID 1w8k

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OCA

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