1vhi

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{{Seed}}
 
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[[Image:1vhi.png|left|200px]]
 
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==EPSTEIN BARR VIRUS NUCLEAR ANTIGEN-1 DNA-BINDING DOMAIN, RESIDUES 470-607==
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The line below this paragraph, containing "STRUCTURE_1vhi", creates the "Structure Box" on the page.
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<StructureSection load='1vhi' size='340' side='right'caption='[[1vhi]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1vhi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_4 Human gammaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VHI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VHI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vhi OCA], [https://pdbe.org/1vhi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vhi RCSB], [https://www.ebi.ac.uk/pdbsum/1vhi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vhi ProSAT]</span></td></tr>
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{{STRUCTURE_1vhi| PDB=1vhi | SCENE= }}
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</table>
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== Function ==
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===EPSTEIN BARR VIRUS NUCLEAR ANTIGEN-1 DNA-BINDING DOMAIN, RESIDUES 470-607===
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[https://www.uniprot.org/uniprot/EBNA1_EBVB9 EBNA1_EBVB9] Plays an essential role in replication and partitioning of viral genomic DNA during latent viral infection. During this phase, the circular double-stranded viral DNA undergoes replication once per cell cycle and is efficiently partitioned to the daughter cells. EBNA1 activates the initiation of viral DNA replication through binding to specific sites in the viral latent origin of replication, oriP. Additionally, it governs the segregation of viral episomes by mediating their attachment to host cell metaphase chromosomes. Also activates the transcription of several viral latency genes. Finally, it can counteract the stabilization of host p53/TP53 by host USP7, thereby decreasing apoptosis and increasing host cell survival.<ref>PMID:15808506</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_7553871}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 7553871 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vh/1vhi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_7553871}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vhi ConSurf].
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1VHI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VHI OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein EBNA 1., Bochkarev A, Barwell JA, Pfuetzner RA, Furey W Jr, Edwards AM, Frappier L, Cell. 1995 Oct 6;83(1):39-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7553871 7553871]
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__TOC__
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[[Category: Human herpesvirus 4]]
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</StructureSection>
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[[Category: Single protein]]
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[[Category: Human gammaherpesvirus 4]]
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[[Category: Barwell, J.]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A.]]
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[[Category: Barwell J]]
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[[Category: Edwards, A.]]
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[[Category: Bochkarev A]]
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[[Category: Frappier, L.]]
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[[Category: Edwards A]]
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[[Category: Furey, W.]]
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[[Category: Frappier L]]
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[[Category: Pfuetzner, R.]]
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[[Category: Furey W]]
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[[Category: Activator]]
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[[Category: Pfuetzner R]]
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[[Category: Dna-binding]]
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[[Category: Nuclear protein]]
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[[Category: Origin-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:03:14 2008''
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Current revision

EPSTEIN BARR VIRUS NUCLEAR ANTIGEN-1 DNA-BINDING DOMAIN, RESIDUES 470-607

PDB ID 1vhi

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