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1mx4

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{{Seed}}
 
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[[Image:1mx4.png|left|200px]]
 
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<!--
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==Structure of p18INK4c (F82Q)==
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The line below this paragraph, containing "STRUCTURE_1mx4", creates the "Structure Box" on the page.
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<StructureSection load='1mx4' size='340' side='right'caption='[[1mx4]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1mx4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MX4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mx4 OCA], [https://pdbe.org/1mx4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mx4 RCSB], [https://www.ebi.ac.uk/pdbsum/1mx4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mx4 ProSAT]</span></td></tr>
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{{STRUCTURE_1mx4| PDB=1mx4 | SCENE= }}
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</table>
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== Function ==
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===Structure of p18INK4c (F82Q)===
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[https://www.uniprot.org/uniprot/CDN2C_HUMAN CDN2C_HUMAN] Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<!--
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_12370184}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 12370184 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mx/1mx4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_12370184}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mx4 ConSurf].
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1MX4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MX4 OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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Structure-based design of p18INK4c proteins with increased thermodynamic stability and cell cycle inhibitory activity., Venkataramani RN, MacLachlan TK, Chai X, El-Deiry WS, Marmorstein R, J Biol Chem. 2002 Dec 13;277(50):48827-33. Epub 2002 Oct 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12370184 12370184]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Chai, X.]]
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[[Category: Chai X]]
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[[Category: El-Deiry, W S.]]
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[[Category: El-Deiry WS]]
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[[Category: MacLachlan, T K.]]
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[[Category: MacLachlan TK]]
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[[Category: Marmorstein, R.]]
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[[Category: Marmorstein R]]
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[[Category: Venkataramani, R N.]]
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[[Category: Venkataramani RN]]
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[[Category: Ankyrin repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:14:59 2008''
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Current revision

Structure of p18INK4c (F82Q)

PDB ID 1mx4

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