3c9r

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{{Seed}}
 
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[[Image:3c9r.png|left|200px]]
 
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==AaThiL complexed with ATP==
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The line below this paragraph, containing "STRUCTURE_3c9r", creates the "Structure Box" on the page.
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<StructureSection load='3c9r' size='340' side='right'caption='[[3c9r]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3c9r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C9R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C9R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3c9s|3c9s]], [[3c9t|3c9t]], [[3c9u|3c9u]]</div></td></tr>
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{{STRUCTURE_3c9r| PDB=3c9r | SCENE= }}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">thiL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 "Aquifex aeolicus" Huber and Stetter 2001])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Thiamine-phosphate_kinase Thiamine-phosphate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.16 2.7.4.16] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c9r OCA], [https://pdbe.org/3c9r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c9r RCSB], [https://www.ebi.ac.uk/pdbsum/3c9r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c9r ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/THIL_AQUAE THIL_AQUAE]] Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.<ref>PMID:18311927</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c9/3c9r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c9r ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Thiamin monophosphate kinase (ThiL) catalyzes the ATP-dependent phosphorylation of thiamin monophosphate (TMP) to form thiamin pyrophosphate (TPP), the active form of vitamin B 1. ThiL is a member of a small ATP binding superfamily that also includes the purine biosynthetic enzymes, PurM and PurL, NiFe hydrogenase maturation protein, HypE, and selenophosphate synthase, SelD. The latter four enzymes are believed to utilize phosphorylated intermediates during catalysis. To understand the mechanism of ThiL and its relationship to the other superfamily members, we determined the structure of Aquifex aeolicus ThiL (AaThiL) with nonhydrolyzable AMP-PCP and TMP, and also with the products of the reaction, ADP and TPP. The results suggest that AaThiL utilizes a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. The structure of ThiL is compared to those of PurM, PurL, and HypE, and the ATP binding site is compared to that of PurL, for which nucleotide complexes are available.
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===AaThiL complexed with ATP===
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Structural studies of thiamin monophosphate kinase in complex with substrates and products(,).,McCulloch KM, Kinsland C, Begley TP, Ealick SE Biochemistry. 2008 Mar 25;47(12):3810-21. Epub 2008 Mar 1. PMID:18311927<ref>PMID:18311927</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_18311927}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3c9r" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18311927 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18311927}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Aquifex aeolicus huber and stetter 2001]]
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3C9R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C9R OCA].
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[[Category: Large Structures]]
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==Reference==
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Structural studies of thiamin monophosphate kinase in complex with substrates and products(,)., McCulloch KM, Kinsland C, Begley TP, Ealick SE, Biochemistry. 2008 Mar 25;47(12):3810-21. Epub 2008 Mar 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18311927 18311927]
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[[Category: Aquifex aeolicus]]
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[[Category: Single protein]]
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[[Category: Thiamine-phosphate kinase]]
[[Category: Thiamine-phosphate kinase]]
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[[Category: Begley, T P.]]
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[[Category: Begley, T P]]
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[[Category: Ealick, S E.]]
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[[Category: Ealick, S E]]
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[[Category: Kinsland, C.]]
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[[Category: Kinsland, C]]
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[[Category: McCulloch, K M.]]
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[[Category: McCulloch, K M]]
[[Category: Alpha-beta structure]]
[[Category: Alpha-beta structure]]
[[Category: Beta barrel]]
[[Category: Beta barrel]]
[[Category: Kinase]]
[[Category: Kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:32:43 2008''
 

Current revision

AaThiL complexed with ATP

PDB ID 3c9r

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