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1qqg

From Proteopedia

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{{Seed}}
 
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[[Image:1qqg.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1==
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The line below this paragraph, containing "STRUCTURE_1qqg", creates the "Structure Box" on the page.
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<StructureSection load='1qqg' size='340' side='right'caption='[[1qqg]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qqg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QQG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqg OCA], [https://pdbe.org/1qqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qqg RCSB], [https://www.ebi.ac.uk/pdbsum/1qqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qqg ProSAT]</span></td></tr>
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{{STRUCTURE_1qqg| PDB=1qqg | SCENE= }}
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</table>
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== Disease ==
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===CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1===
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[https://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN] Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:[https://omim.org/entry/125853 125853].<ref>PMID:14707024</ref> <ref>PMID:8723689</ref> <ref>PMID:10206679</ref> <ref>PMID:12843189</ref> <ref>PMID:15590636</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/IRS1_HUMAN IRS1_HUMAN] May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).<ref>PMID:16878150</ref> <ref>PMID:14707024</ref>
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== Evolutionary Conservation ==
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The line below this paragraph, {{ABSTRACT_PUBMED_10411883}}, adds the Publication Abstract to the page
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[[Image:Consurf_key_small.gif|200px|right]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10411883 is the PubMed ID number.
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Check<jmol>
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<jmolCheckbox>
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{{ABSTRACT_PUBMED_10411883}}
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qq/1qqg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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==About this Structure==
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<text>to colour the structure by Evolutionary Conservation</text>
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1QQG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQG OCA].
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qqg ConSurf].
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==Reference==
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<div style="clear:both"></div>
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Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1., Dhe-Paganon S, Ottinger EA, Nolte RT, Eck MJ, Shoelson SE, Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8378-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10411883 10411883]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dhe-Paganon, S.]]
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[[Category: Dhe-Paganon S]]
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[[Category: Shoelson, S E.]]
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[[Category: Shoelson SE]]
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[[Category: Beta-sandwhich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:48:31 2008''
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Current revision

CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1

PDB ID 1qqg

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