1vry

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{{Seed}}
 
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[[Image:1vry.png|left|200px]]
 
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==Second and Third Transmembrane Domains of the Alpha-1 Subunit of Human Glycine Receptor==
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The line below this paragraph, containing "STRUCTURE_1vry", creates the "Structure Box" on the page.
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<StructureSection load='1vry' size='340' side='right'caption='[[1vry]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1vry]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1zhd 1zhd]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VRY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vry OCA], [https://pdbe.org/1vry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vry RCSB], [https://www.ebi.ac.uk/pdbsum/1vry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vry ProSAT]</span></td></tr>
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{{STRUCTURE_1vry| PDB=1vry | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/GLRA1_HUMAN GLRA1_HUMAN] Defects in GLRA1 are the cause of hyperekplexia, hereditary, type 1 (HKPX1) [MIM:[https://omim.org/entry/149400 149400]. A neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli.<ref>PMID:8298642</ref> [:]<ref>PMID:7925268</ref> <ref>PMID:7981700</ref> <ref>PMID:7881416</ref> <ref>PMID:7611730</ref> <ref>PMID:8571969</ref> <ref>PMID:8733061</ref> <ref>PMID:9067762</ref> <ref>PMID:10514101</ref> <ref>PMID:9920650</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/GLRA1_HUMAN GLRA1_HUMAN] The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vr/1vry_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vry ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A 61-residue polypeptide resembling the second and third transmembrane domains (TM23) of the alpha-1 subunit of human glycine receptor and its truncated form, both with the wild-type loop linking the two TM domains (the "23" loop), were studied using high-resolution NMR. Well-defined domain structures can be identified for the TM2, 23 loop, and TM3 regions. Contrary to the popular model of a long and straight alpha-helical structure for the pore-lining TM2 domain for the Cys-loop receptor family, the last three residues of the TM2 domain and the first eight residues of the 23 loop (S16-S26) seem to be intrinsically nonhelical and highly flexible even in trifluoroethanol, a solvent known to promote and stabilize alpha-helical structures. The six remaining residues of the 23 loop and most of the TM3 domain exhibit helical structures with a kinked pi-helix (or a pi-turn) from W34 to C38 and a kink angle of 159 +/- 3 degrees . The tertiary fold of TM3 relative to TM2 is defined by several unambiguously identified long-range NOE cross-peaks within the loop region and between TM2 and TM3 domains. The 20 lowest-energy structures show a left-handed tilt of TM3 relative to TM2 with a tilting angle of 44 +/- 2 degrees between TM2 (V1-Q14) and TM3 (L39-E48) helix axes. This left-handed TM2-TM3 arrangement ensures a neatly packed right-handed quaternary structure of five subunits to form an ion-conducting pore. This is the first time that two TM domains of the glycine receptor linked by the important 23 loop have ever been analyzed at atomistic resolution. Many structural characteristics of the receptor can be inferred from the structural and dynamical features identified in this study.
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===Second and Third Transmembrane Domains of the Alpha-1 Subunit of Human Glycine Receptor===
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Structure and dynamics of the second and third transmembrane domains of human glycine receptor.,Ma D, Liu Z, Li L, Tang P, Xu Y Biochemistry. 2005 Jun 21;44(24):8790-800. PMID:15952785<ref>PMID:15952785</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15952785}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1vry" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15952785 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15952785}}
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__TOC__
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</StructureSection>
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==Disease==
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Known disease associated with this structure: Hyperekplexia and spastic paraparesis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138491 138491]], Startle disease, autosomal recessive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138491 138491]], Startle disease/hyperekplexia, autosomal dominant OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138491 138491]]
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==About this Structure==
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1VRY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1zhd 1zhd]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VRY OCA].
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==Reference==
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Structure and dynamics of the second and third transmembrane domains of human glycine receptor., Ma D, Liu Z, Li L, Tang P, Xu Y, Biochemistry. 2005 Jun 21;44(24):8790-800. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15952785 15952785]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Li, L.]]
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[[Category: Li L]]
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[[Category: Liu, Z.]]
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[[Category: Liu Z]]
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[[Category: Ma, D.]]
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[[Category: Ma D]]
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[[Category: Tang, P.]]
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[[Category: Tang P]]
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[[Category: Xu, Y.]]
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[[Category: Xu Y]]
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[[Category: Glycine receptor]]
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[[Category: Nmr]]
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[[Category: Second transmembrane domain]]
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[[Category: Third transmembrane domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:51:58 2008''
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Current revision

Second and Third Transmembrane Domains of the Alpha-1 Subunit of Human Glycine Receptor

PDB ID 1vry

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