2bay

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{{Seed}}
 
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[[Image:2bay.png|left|200px]]
 
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==Crystal structure of the Prp19 U-box dimer==
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The line below this paragraph, containing "STRUCTURE_2bay", creates the "Structure Box" on the page.
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<StructureSection load='2bay' size='340' side='right'caption='[[2bay]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2bay]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BAY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bay OCA], [https://pdbe.org/2bay PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bay RCSB], [https://www.ebi.ac.uk/pdbsum/2bay PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bay ProSAT]</span></td></tr>
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{{STRUCTURE_2bay| PDB=2bay | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PRP19_YEAST PRP19_YEAST] Involved in pre-mRNA splicing. Acts a central component of the NTC complex (or PRP19-associated complex) that associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation. Involved in DNA repair.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ba/2bay_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bay ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the Prp19 U-box dimer===
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==See Also==
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*[[Pre-mRNA splicing factors 3D structures|Pre-mRNA splicing factors 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_16388587}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16388587 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16388587}}
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==About this Structure==
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2BAY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BAY OCA].
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==Reference==
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The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquitin ligases., Vander Kooi CW, Ohi MD, Rosenberg JA, Oldham ML, Newcomer ME, Gould KL, Chazin WJ, Biochemistry. 2006 Jan 10;45(1):121-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16388587 16388587]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Chazin WJ]]
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[[Category: Chazin, W J.]]
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[[Category: Gould KL]]
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[[Category: Gould, K L.]]
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[[Category: Newcomer ME]]
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[[Category: Kooi, C W.Vander.]]
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[[Category: Ohi MD]]
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[[Category: Newcomer, M E.]]
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[[Category: Oldham ML]]
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[[Category: Ohi, M D.]]
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[[Category: Rosenberg JA]]
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[[Category: Oldham, M L.]]
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[[Category: Vander Kooi CW]]
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[[Category: Rosenberg, J A.]]
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[[Category: E3 ligase]]
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[[Category: Prp19]]
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[[Category: U-box]]
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[[Category: Ubiquitin ligase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:00:46 2008''
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Current revision

Crystal structure of the Prp19 U-box dimer

PDB ID 2bay

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OCA

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