2qna

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{{Seed}}
 
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[[Image:2qna.png|left|200px]]
 
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==Crystal structure of human Importin-beta (127-876) in complex with the IBB-domain of Snurportin1 (1-65)==
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The line below this paragraph, containing "STRUCTURE_2qna", creates the "Structure Box" on the page.
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<StructureSection load='2qna' size='340' side='right'caption='[[2qna]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2qna]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QNA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.84&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2qna| PDB=2qna | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qna OCA], [https://pdbe.org/2qna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qna RCSB], [https://www.ebi.ac.uk/pdbsum/2qna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qna ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IMB1_HUMAN IMB1_HUMAN] Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports PRKCI into the nucleus.<ref>PMID:9687515</ref> <ref>PMID:10228156</ref> <ref>PMID:11891849</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qn/2qna_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qna ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human Importin-beta (127-876) in complex with the IBB-domain of Snurportin1 (1-65)===
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==See Also==
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*[[Importin 3D structures|Importin 3D structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18028944 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18028944}}
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==About this Structure==
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2QNA is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QNA OCA].
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==Reference==
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Structural basis for RanGTP independent entry of spliceosomal U snRNPs into the nucleus., Wohlwend D, Strasser A, Dickmanns A, Ficner R, J Mol Biol. 2007 Dec 7;374(4):1129-38. Epub 2007 Sep 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18028944 18028944]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Dickmanns, A.]]
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[[Category: Dickmanns A]]
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[[Category: Ficner, R.]]
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[[Category: Ficner R]]
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[[Category: Strasser, A.]]
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[[Category: Strasser A]]
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[[Category: Wohlwend, D.]]
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[[Category: Wohlwend D]]
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[[Category: Acetylation]]
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[[Category: Cytoplasm]]
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[[Category: Heat-repeat protein]]
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[[Category: Host-virus interaction]]
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[[Category: Import of spliceosomal subunit]]
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[[Category: Nuclear transport]]
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[[Category: Nucleus]]
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[[Category: Protein transport]]
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[[Category: Protein-protein interaction]]
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[[Category: Rna-binding]]
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[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:05:41 2008''
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Current revision

Crystal structure of human Importin-beta (127-876) in complex with the IBB-domain of Snurportin1 (1-65)

PDB ID 2qna

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