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2rfa

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{{Seed}}
 
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[[Image:2rfa.png|left|200px]]
 
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==Crystal structure of the mouse TRPV6 ankyrin repeat domain==
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The line below this paragraph, containing "STRUCTURE_2rfa", creates the "Structure Box" on the page.
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<StructureSection load='2rfa' size='340' side='right'caption='[[2rfa]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2rfa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RFA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rfa OCA], [https://pdbe.org/2rfa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rfa RCSB], [https://www.ebi.ac.uk/pdbsum/2rfa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rfa ProSAT]</span></td></tr>
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{{STRUCTURE_2rfa| PDB=2rfa | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRPV6_MOUSE TRPV6_MOUSE] Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.<ref>PMID:12601087</ref> <ref>PMID:12574114</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rf/2rfa_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rfa ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the mouse TRPV6 ankyrin repeat domain===
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==See Also==
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18232717 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_18232717}}
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==About this Structure==
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2RFA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RFA OCA].
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==Reference==
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Structural Analyses of the Ankyrin Repeat Domain of TRPV6 and Related TRPV Ion Channels(,)., Phelps CB, Huang RJ, Lishko PV, Wang RR, Gaudet R, Biochemistry. 2008 Feb 26;47(8):2476-84. Epub 2008 Jan 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18232717 18232717]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Gaudet R]]
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[[Category: Gaudet, R.]]
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[[Category: Huang RJ]]
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[[Category: Huang, R J.]]
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[[Category: Phelps CB]]
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[[Category: Phelps, C B.]]
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[[Category: Wang RR]]
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[[Category: Wang, R R.]]
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[[Category: Ank repeat]]
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[[Category: Ankyrin reapeat]]
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[[Category: Calcium]]
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[[Category: Calcium channel]]
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[[Category: Calcium transport]]
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[[Category: Calmodulin-binding]]
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[[Category: Glycoprotein]]
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[[Category: Ion transport]]
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[[Category: Ionic channel]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Transient receptor potential]]
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[[Category: Transmembrane]]
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[[Category: Transport]]
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[[Category: Trpv6]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:08:39 2008''
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Current revision

Crystal structure of the mouse TRPV6 ankyrin repeat domain

PDB ID 2rfa

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