2d5v

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{{Seed}}
 
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[[Image:2d5v.png|left|200px]]
 
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==Crystal structure of HNF-6alpha DNA-binding domain in complex with the TTR promoter==
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The line below this paragraph, containing "STRUCTURE_2d5v", creates the "Structure Box" on the page.
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<StructureSection load='2d5v' size='340' side='right'caption='[[2d5v]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2d5v]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D5V FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_2d5v| PDB=2d5v | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d5v OCA], [https://pdbe.org/2d5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d5v RCSB], [https://www.ebi.ac.uk/pdbsum/2d5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d5v ProSAT]</span></td></tr>
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</table>
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===Crystal structure of HNF-6alpha DNA-binding domain in complex with the TTR promoter===
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== Function ==
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[https://www.uniprot.org/uniprot/HNF6_RAT HNF6_RAT] Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. The affinity of HNF-6-alpha and HNF-6-beta for DNA differs depending on the target sequence.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_17223534}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 17223534 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d5/2d5v_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_17223534}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2D5V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D5V OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d5v ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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DNA recognition mechanism of the ONECUT homeodomain of transcription factor HNF-6., Iyaguchi D, Yao M, Watanabe N, Nishihira J, Tanaka I, Structure. 2007 Jan;15(1):75-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17223534 17223534]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Iyaguchi D]]
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[[Category: Iyaguchi, D.]]
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[[Category: Nishihira J]]
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[[Category: Nishihira, J.]]
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[[Category: Tanaka I]]
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[[Category: Tanaka, I.]]
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[[Category: Watanabe N]]
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[[Category: Watanabe, N.]]
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[[Category: Yao M]]
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[[Category: Yao, M.]]
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[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:11:19 2008''
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Current revision

Crystal structure of HNF-6alpha DNA-binding domain in complex with the TTR promoter

PDB ID 2d5v

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