3bdw

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{{Seed}}
 
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[[Image:3bdw.png|left|200px]]
 
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==Human CD94/NKG2A==
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The line below this paragraph, containing "STRUCTURE_3bdw", creates the "Structure Box" on the page.
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<StructureSection load='3bdw' size='340' side='right'caption='[[3bdw]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3bdw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BDW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BDW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bdw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bdw OCA], [https://pdbe.org/3bdw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bdw RCSB], [https://www.ebi.ac.uk/pdbsum/3bdw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bdw ProSAT]</span></td></tr>
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{{STRUCTURE_3bdw| PDB=3bdw | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KLRD1_HUMAN KLRD1_HUMAN] Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bd/3bdw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bdw ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The CD94-NKG2 receptor family that regulates NK and T cells is unique among the lectin-like receptors encoded within the natural killer cell complex. The function of the CD94-NKG2 receptors is dictated by the pairing of the invariant CD94 polypeptide with specific NKG2 isoforms to form a family of functionally distinct heterodimeric receptors. However, the structural basis for this selective pairing and how they interact with their ligand, HLA-E, is unknown. We describe the 2.5 A resolution crystal structure of CD94-NKG2A in which the mode of dimerization contrasts with that of other homodimeric NK receptors. Despite structural homology between the CD94 and NKG2A subunits, the dimer interface is asymmetric, thereby providing a structural basis for the preferred heterodimeric assembly. Structure-based sequence comparisons of other CD94-NKG2 family members, combined with extensive mutagenesis studies on HLA-E and CD94-NKG2A, allows a model of the interaction between CD94-NKG2A and HLA-E to be established, in which the invariant CD94 chain plays a more dominant role in interacting with HLA-E in comparison to the variable NKG2 chain.
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===Human CD94/NKG2A===
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The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition.,Sullivan LC, Clements CS, Beddoe T, Johnson D, Hoare HL, Lin J, Huyton T, Hopkins EJ, Reid HH, Wilce MC, Kabat J, Borrego F, Coligan JE, Rossjohn J, Brooks AG Immunity. 2007 Dec;27(6):900-11. PMID:18083576<ref>PMID:18083576</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3bdw" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18083576}}, adds the Publication Abstract to the page
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*[[NK cell receptor|NK cell receptor]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18083576 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18083576}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3BDW is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BDW OCA].
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==Reference==
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The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition., Sullivan LC, Clements CS, Beddoe T, Johnson D, Hoare HL, Lin J, Huyton T, Hopkins EJ, Reid HH, Wilce MC, Kabat J, Borrego F, Coligan JE, Rossjohn J, Brooks AG, Immunity. 2007 Dec;27(6):900-11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18083576 18083576]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Clements, C S.]]
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[[Category: Clements CS]]
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[[Category: Sullivan, L C.]]
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[[Category: Sullivan LC]]
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[[Category: Alternative splicing]]
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[[Category: Glycoprotein]]
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[[Category: Immune system receptor]]
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[[Category: Lectin]]
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[[Category: Membrane]]
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[[Category: Nk cell]]
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[[Category: Receptor]]
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[[Category: Signal-anchor]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:16:58 2008''
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Current revision

Human CD94/NKG2A

PDB ID 3bdw

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