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2g86

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{{Seed}}
 
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[[Image:2g86.png|left|200px]]
 
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==L. casei thymidylate synthase Y261F in complex with substrate, dUMP==
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The line below this paragraph, containing "STRUCTURE_2g86", creates the "Structure Box" on the page.
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<StructureSection load='2g86' size='340' side='right'caption='[[2g86]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2g86]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G86 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G86 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
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{{STRUCTURE_2g86| PDB=2g86 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g86 OCA], [https://pdbe.org/2g86 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g86 RCSB], [https://www.ebi.ac.uk/pdbsum/2g86 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g86 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA] Provides the sole de novo source of dTMP for DNA biosynthesis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/2g86_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g86 ConSurf].
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<div style="clear:both"></div>
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===L. casei thymidylate synthase Y261F in complex with substrate, dUMP===
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==See Also==
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*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_16768437}}, adds the Publication Abstract to the page
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[[Category: Lacticaseibacillus casei]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16768437 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Finer-Moore JS]]
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{{ABSTRACT_PUBMED_16768437}}
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[[Category: Stroud RM]]
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==About this Structure==
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2G86 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G86 OCA].
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==Reference==
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The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261., Newby Z, Lee TT, Morse RJ, Liu Y, Liu L, Venkatraman P, Santi DV, Finer-Moore JS, Stroud RM, Biochemistry. 2006 Jun 20;45(24):7415-28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16768437 16768437]
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[[Category: Lactobacillus casei]]
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[[Category: Single protein]]
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[[Category: Thymidylate synthase]]
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[[Category: Finer-Moore, J S.]]
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[[Category: Stroud, R M.]]
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[[Category: Dump complex]]
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[[Category: Dump-binding residue]]
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[[Category: Thymidylate synthase mutant]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:21:39 2008''
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Current revision

L. casei thymidylate synthase Y261F in complex with substrate, dUMP

PDB ID 2g86

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