This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1n6b

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:53, 14 February 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1n6b.png|left|200px]]
 
-
<!--
+
==Microsomal Cytochrome P450 2C5/3LVdH Complex with a dimethyl derivative of sulfaphenazole==
-
The line below this paragraph, containing "STRUCTURE_1n6b", creates the "Structure Box" on the page.
+
<StructureSection load='1n6b' size='340' side='right'caption='[[1n6b]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1n6b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N6B FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMZ:4-METHYL-N-METHYL-N-(2-PHENYL-2H-PYRAZOL-3-YL)BENZENESULFONAMIDE'>DMZ</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_1n6b| PDB=1n6b | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n6b OCA], [https://pdbe.org/1n6b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n6b RCSB], [https://www.ebi.ac.uk/pdbsum/1n6b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n6b ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CP2C5_RABIT CP2C5_RABIT] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n6/1n6b_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n6b ConSurf].
 +
<div style="clear:both"></div>
-
===Microsomal Cytochrome P450 2C5/3LVdH Complex with a dimethyl derivative of sulfaphenazole===
+
==See Also==
-
 
+
*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
-
 
+
__TOC__
-
<!--
+
</StructureSection>
-
The line below this paragraph, {{ABSTRACT_PUBMED_12767218}}, adds the Publication Abstract to the page
+
[[Category: Large Structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 12767218 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_12767218}}
+
-
 
+
-
==About this Structure==
+
-
1N6B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6B OCA].
+
-
 
+
-
==Reference==
+
-
Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes., Wester MR, Johnson EF, Marques-Soares C, Dansette PM, Mansuy D, Stout CD, Biochemistry. 2003 Jun 3;42(21):6370-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12767218 12767218]
+
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
-
[[Category: Single protein]]
+
[[Category: Dansette PM]]
-
[[Category: Unspecific monooxygenase]]
+
[[Category: Johnson EF]]
-
[[Category: Dansette, P M.]]
+
[[Category: Mansuy D]]
-
[[Category: Johnson, E F.]]
+
[[Category: Marques-Soares C]]
-
[[Category: Mansuy, D.]]
+
[[Category: Stout CD]]
-
[[Category: Marques-Soares, C.]]
+
[[Category: Wester MR]]
-
[[Category: Stout, C D.]]
+
-
[[Category: Wester, M R.]]
+
-
[[Category: Cyp2c5]]
+
-
[[Category: Dimethylsulfaphenazole complex]]
+
-
[[Category: Estradiol 2-hydroxylase]]
+
-
[[Category: Membrane protein]]
+
-
[[Category: P450]]
+
-
[[Category: Progesterone 21-hydroxylase]]
+
-
[[Category: Pyrene hydroxylase]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:33:52 2008''
+

Current revision

Microsomal Cytochrome P450 2C5/3LVdH Complex with a dimethyl derivative of sulfaphenazole

PDB ID 1n6b

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1n6b"
Personal tools