1lrh

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(New page: 200px<br /><applet load="1lrh" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lrh, resolution 1.9&Aring;" /> '''Crystal structure of ...)
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[[Image:1lrh.gif|left|200px]]<br /><applet load="1lrh" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1lrh, resolution 1.9&Aring;" />
 
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'''Crystal structure of auxin-binding protein 1 in complex with 1-naphthalene acetic acid'''<br />
 
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==Overview==
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==Crystal structure of auxin-binding protein 1 in complex with 1-naphthalene acetic acid==
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The structure of auxin-binding protein 1 (ABP1) from maize has been, determined at 1.9 A resolution, revealing its auxin-binding site. The, structure confirms that ABP1 belongs to the ancient and functionally, diverse germin/seed storage 7S protein superfamily. The binding pocket of, ABP1 is predominantly hydrophobic with a metal ion deep inside the pocket, coordinated by three histidines and a glutamate. Auxin binds within this, pocket, with its carboxylate binding the zinc and its aromatic ring, binding hydrophobic residues including Trp151. There is a single disulfide, between Cys2 and Cys155. No conformational rearrangement of ABP1 was, observed when auxin bound to the protein in the crystal, but examination, of the structure reveals a possible mechanism of signal transduction.
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<StructureSection load='1lrh' size='340' side='right'caption='[[1lrh]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1lrh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Zea_mays Zea mays]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LRH FirstGlance]. <br>
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1LRH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Zea_mays Zea mays] with ZN and NLA as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1LRH OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NLA:NAPHTHALEN-1-YL-ACETIC+ACID'>NLA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lrh OCA], [https://pdbe.org/1lrh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lrh RCSB], [https://www.ebi.ac.uk/pdbsum/1lrh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lrh ProSAT]</span></td></tr>
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Crystal structure of auxin-binding protein 1 in complex with auxin., Woo EJ, Marshall J, Bauly J, Chen JG, Venis M, Napier RM, Pickersgill RW, EMBO J. 2002 Jun 17;21(12):2877-85. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12065401 12065401]
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</table>
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[[Category: Single protein]]
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== Function ==
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[https://www.uniprot.org/uniprot/ABP1_MAIZE ABP1_MAIZE] This is probably a receptor for the plant hormone auxin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lr/1lrh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lrh ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Zea mays]]
[[Category: Zea mays]]
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[[Category: Bauly, J.]]
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[[Category: Bauly J]]
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[[Category: Chen, J.G.]]
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[[Category: Chen J-G]]
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[[Category: Marshall, J.]]
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[[Category: Marshall J]]
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[[Category: Napier, R.M.]]
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[[Category: Napier RM]]
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[[Category: Pickersgill, R.W.]]
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[[Category: Pickersgill RW]]
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[[Category: Venis, M.]]
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[[Category: Venis M]]
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[[Category: Woo, E.J.]]
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[[Category: Woo EJ]]
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[[Category: NLA]]
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[[Category: ZN]]
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[[Category: beta jellyroll]]
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[[Category: double stranded parallel beta helix]]
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[[Category: germin like protein]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 20:48:32 2007''
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Current revision

Crystal structure of auxin-binding protein 1 in complex with 1-naphthalene acetic acid

PDB ID 1lrh

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