2dr6

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{{Seed}}
 
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[[Image:2dr6.png|left|200px]]
 
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==Crystal structure of a multidrug transporter reveal a functionally rotating mechanism==
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The line below this paragraph, containing "STRUCTURE_2dr6", creates the "Structure Box" on the page.
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<StructureSection load='2dr6' size='340' side='right'caption='[[2dr6]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2dr6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DR6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DR6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DM2:DOXORUBICIN'>DM2</scene></td></tr>
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{{STRUCTURE_2dr6| PDB=2dr6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dr6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dr6 OCA], [https://pdbe.org/2dr6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dr6 RCSB], [https://www.ebi.ac.uk/pdbsum/2dr6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dr6 ProSAT]</span></td></tr>
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</table>
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===Crystal structure of a multidrug transporter reveal a functionally rotating mechanism===
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== Function ==
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[https://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_16915237}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 16915237 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dr/2dr6_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_16915237}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2DR6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DR6 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dr6 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Crystal structures of a multidrug transporter reveal a functionally rotating mechanism., Murakami S, Nakashima R, Yamashita E, Matsumoto T, Yamaguchi A, Nature. 2006 Sep 14;443(7108):173-9. Epub 2006 Aug 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16915237 16915237]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Matsumoto, T.]]
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[[Category: Matsumoto T]]
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[[Category: Murakami, S.]]
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[[Category: Murakami S]]
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[[Category: Nakashima, R.]]
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[[Category: Nakashima R]]
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[[Category: Yamashita, E.]]
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[[Category: Yamashita E]]
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[[Category: Antiporter]]
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[[Category: Drug resistance]]
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[[Category: Exporter]]
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[[Category: Membrane protein]]
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[[Category: Membrane transporter]]
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[[Category: Multidrug efflux]]
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[[Category: Transporter]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:38:15 2008''
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Current revision

Crystal structure of a multidrug transporter reveal a functionally rotating mechanism

PDB ID 2dr6

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