3fis

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{{Seed}}
 
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[[Image:3fis.png|left|200px]]
 
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==THE MOLECULAR STRUCTURE OF WILD-TYPE AND A MUTANT FIS PROTEIN: RELATIONSHIP BETWEEN MUTATIONAL CHANGES AND RECOMBINATIONAL ENHANCER FUNCTION OR DNA BINDING==
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The line below this paragraph, containing "STRUCTURE_3fis", creates the "Structure Box" on the page.
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<StructureSection load='3fis' size='340' side='right'caption='[[3fis]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3fis]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FIS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fis OCA], [https://pdbe.org/3fis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fis RCSB], [https://www.ebi.ac.uk/pdbsum/3fis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fis ProSAT]</span></td></tr>
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{{STRUCTURE_3fis| PDB=3fis | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FIS_ECOLI FIS_ECOLI] Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin-mediated DNA inversion. Prevents initiation of DNA replication from oriC.<ref>PMID:2209559</ref> <ref>PMID:8836178</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fi/3fis_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fis ConSurf].
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<div style="clear:both"></div>
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===THE MOLECULAR STRUCTURE OF WILD-TYPE AND A MUTANT FIS PROTEIN: RELATIONSHIP BETWEEN MUTATIONAL CHANGES AND RECOMBINATIONAL ENHANCER FUNCTION OR DNA BINDING===
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==See Also==
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*[[FIS protein|FIS protein]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 1946369 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_1946369}}
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==About this Structure==
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3FIS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FIS OCA].
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==Reference==
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The molecular structure of wild-type and a mutant Fis protein: relationship between mutational changes and recombinational enhancer function or DNA binding., Yuan HS, Finkel SE, Feng JA, Kaczor-Grzeskowiak M, Johnson RC, Dickerson RE, Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9558-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1946369 1946369]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dickerson, R E.]]
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[[Category: Dickerson RE]]
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[[Category: Feng, J-A.]]
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[[Category: Feng J-A]]
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[[Category: Finkel, S E.]]
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[[Category: Finkel SE]]
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[[Category: Johnson, R C.]]
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[[Category: Johnson RC]]
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[[Category: Yuan, H S.]]
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[[Category: Yuan HS]]
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[[Category: Dna-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:56:10 2008''
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Current revision

THE MOLECULAR STRUCTURE OF WILD-TYPE AND A MUTANT FIS PROTEIN: RELATIONSHIP BETWEEN MUTATIONAL CHANGES AND RECOMBINATIONAL ENHANCER FUNCTION OR DNA BINDING

PDB ID 3fis

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