1z92

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{{Seed}}
 
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[[Image:1z92.png|left|200px]]
 
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==structure of interleukin-2 with its alpha receptor==
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The line below this paragraph, containing "STRUCTURE_1z92", creates the "Structure Box" on the page.
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<StructureSection load='1z92' size='340' side='right'caption='[[1z92]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1z92]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z92 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z92 OCA], [https://pdbe.org/1z92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z92 RCSB], [https://www.ebi.ac.uk/pdbsum/1z92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z92 ProSAT]</span></td></tr>
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{{STRUCTURE_1z92| PDB=1z92 | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
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== Function ==
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[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z9/1z92_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z92 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Interleukin-2 (IL-2) is an immunoregulatory cytokine that binds sequentially to the alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits. Here we present the 2.8 angstrom crystal structure of a complex between human IL-2 and IL-2Ralpha, which interact in a docking mode distinct from that of other cytokine receptor complexes. IL-2Ralpha is composed of strand-swapped "sushi-like" domains, unlike the classical cytokine receptor fold. As a result of this domain swap, IL-2Ralpha uses a composite surface to dock into a groove on IL-2 that also serves as a binding site for antagonist drugs. With this complex, we now have representative structures for each class of hematopoietic cytokine receptor-docking modules.
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===structure of interleukin-2 with its alpha receptor===
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The structure of interleukin-2 complexed with its alpha receptor.,Rickert M, Wang X, Boulanger MJ, Goriatcheva N, Garcia KC Science. 2005 Jun 3;308(5727):1477-80. PMID:15933202<ref>PMID:15933202</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1z92" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15933202}}, adds the Publication Abstract to the page
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15933202 is the PubMed ID number.
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*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_15933202}}
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<references/>
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__TOC__
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==Disease==
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</StructureSection>
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Known disease associated with this structure: Severe combined immunodeficiency due to IL2 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147680 147680]], Interleukin-2 receptor, alpha chain, deficiency of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147730 147730]], Diabetes mellitus, insulin-dependent, susceptibility to, 10 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147730 147730]]
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==About this Structure==
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1Z92 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z92 OCA].
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==Reference==
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The structure of interleukin-2 complexed with its alpha receptor., Rickert M, Wang X, Boulanger MJ, Goriatcheva N, Garcia KC, Science. 2005 Jun 3;308(5727):1477-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15933202 15933202]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Boulanger, M J.]]
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[[Category: Boulanger MJ]]
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[[Category: Garcia, K C.]]
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[[Category: Garcia KC]]
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[[Category: Goriatcheva, N.]]
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[[Category: Goriatcheva N]]
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[[Category: Rickert, M.]]
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[[Category: Rickert M]]
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[[Category: Wang, X Q.]]
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[[Category: Wang XQ]]
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[[Category: Interleukin-2]]
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[[Category: Interleukin-2 alpha receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:16:39 2008''
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Current revision

structure of interleukin-2 with its alpha receptor

PDB ID 1z92

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